TN 12th Question Paper 2026 Microbiology

FOR TN 12TH EXAM PREPARATION

TN 12th 2026
Question Paper ·
Microbiology
EXAM YEAR TYPE SUBJECT

TN 12th 2026 Question Paper Microbiology

Notes · Sample Papers · Previous Year Papers · Mock Tests

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No. of Printed Pages : 8
9062

!9062Microbiology! £vÄ Gs
Register Number

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: 3.00 ] [ ö©õzu ©v¨ö£sPÒ : 70

Time Allowed : 3.00 Hours ] [ Maximum Marks : 70

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Instructions : (1) Check the question paper for fairness of printing. If there is any lack of fairness,

inform the Hall Supervisor immediately.

(2) Use Blue or Black ink to write and underline and pencil to draw diagrams.

(3) Draw diagrams wherever necessary.

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Note : (i) Answer all the questions.

(ii) Choose the most appropriate answer from the given four alternatives and write

the option code and the corresponding answer.

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9062 2

1. Jΰ¯À ¤®£ öuõÈÀ~m£zvØS __________ J¸ Euõµn®.
(A) CLSM (B) LCSM

(C) (A) ©ØÖ® (B) (D) TEM

__________ is an example for optical imaging technique.

(a) CLSM (b) LCSM

(c) Both (a) and (b) (d) TEM

2. TEM CÀ £¯ß£kzu¨£k® ö»ßì Gߣx __________.

(A) Psnõi ö»ß_PÒ (B) ö£õ¸Í¸S ö»ß_PÒ
(C) Pshßéº ö»ß_PÒ (D) ªßPõ¢u ö»ß_PÒ
Lens used in TEM is __________.

(a) Glass lenses (b) Objective lens

(c) Condenser lenses (d) Electromagnetic lens

3. »[S v_UPÎÀ ÷|õ´ öuõØøÓ ukUP A¢÷|õ´ Põµoø¯ öPõÀ¾ÁuØS
AÀ»x Áͺa]ø¯ uk¨£uØS £¯ß£kQÓx. __________

(A) iìCßö£Uhßm (B) £õUj›÷¯õìhõiU Põµo
(C) Bßiö\¨iU (D) ÷\Ûøh\º
__________ is used to prevent infection by killing or inhibiting pathogen growth on animal

tissue.

(a) Disinfectant (b) Bacteriostatic agent

(c) Antiseptic (d) Sanitizer

4. ¤ßÁ¸ÁÚÁØÔÀ GøÁ \›¯õÚx ?
(A) A÷£õGßø\® ÷íõ÷»õGßø\® ÷PõGßø\®
+ =

(B) A÷£õGßø\® ÷Põ£õUhº ÷íõ÷»õGßø\®
+ =

(C) ÷PõGßø\® ÷Põ£õUhº ÷íõ÷»õGßø\®
+ =

(D) ÷íõ÷»õGßø\® ÷PõGßø\® A÷£õGßø\®
+ =

Which one of the following is correct ?

(a) Apoenzyme+Holoenzyme =Coenzyme

(b) Apoenzyme+Cofactor =Holoenzyme

(c) Coenzyme+Cofactor =Holoenzyme

(d) Holoenzyme+Coenzyme =Apoenzyme

For more Question Papers, Sample Papers, Notes & Syllabus visit Page 2 of 8

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5. EnÂÀ ~sq°›PÒ ÁͺÁuØS ÷uøÁ¯õÚ SøÓ¢u£m\ aw __________ BP
C¸UP ÷Ásk® .

(A) 0.78 (B) (C) (D)
0.99 0.50 0.86

The minimum value of aw for the growth of the micro organisms in foods should be

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around __________.

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(a) 0.78 (b) 0.99 (c) 0.50 (d) 0.86

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(A) ‰ßÓõ® (B) Cµshõ®
(C) \©{ø» (D) •uÀ{ø»
_________ metabolites are produced in small quantities during industrial production.

(a) Tertiary (b) Secondary

(c) Neutral (d) Primary

7. ö©mhõS÷µõ©õiU SÖ©oPøÍ öPõskÒÍ Qµõ® £õ]miÆ £õ]Àø», ^Ú
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GÊzxUPøÍ ÷£õßÓ Aø©¨¤À Põn¨£k® £s¦PøÍ öPõshøÁ
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(A) ÷£]À»ì B¢uõµõ]ì
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(C) QÍõìi›i¯® ö£º£µg\ßì
(D) ø©U÷Põ£õUj›¯® j²£ºS÷Íõêì
A gram-positive bacilli possessing metachromatic granules, showing Chinese letters

arrangement are characteristic of :

(a) Bacillus anthracis

(b) Corynebacterium diphtheriae

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(c) Clostridium perfringens

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(d) Mycobacterium tuberculosis

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8. __________ .

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(C) \õPõì ÷|õ´ (D) A«¤¯õêì
Flask shaped ulcers in human intestine are related to __________.

(a) Leishmania (b) Giardiasis

(c) Chaga’s disease (d) Amoebiasis

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9062 4

9. __________ ‰»® Aøn¯õøh ui¨¦PÒ (Diaper rash) HØ£kQÓx.
(A) ÷Pßii¯õ]ì (B) öhº÷©÷hõø£mì
(C) Q›¨÷hõPõUPêì (D) îì÷hõ¨£Íõì÷©õ]ì
Diaper rash is caused by __________.

(a) Candidiasis (b) Dermatophytes

(c) Cryptococcosis (d) Histoplasmosis

10. ø\m÷hõö©Põ÷»õ øÁµìPÒ __________ GßÖ® AøÇUP¨£k® .

(A) |õͪÀ»õa_µ¨¤ (Gß÷hõUøµß) øÁµì
(B) EªÌ}º _µ¨¤ øÁµì
(C) öía.I.Â
(D) ö|g\U Pøn¯a _µ¨¤ (øu©ì) øÁµì
Cytomegalo viruses are also called as __________.

(a) Endocrine gland virus

(b) Salivary gland virus

(c) HIV

(d) Thymus gland virus

11. ÁøP II ªøP Tº EnºÄ ÂøÚ°À __________ Dk£kQÓx.
(A) IgM Bßi£õi (B) IgG Bßi£õi
(C) IgE Bßi£õi (D) IgG ©ØÖ® IgM Bßi£õiPÒ
In type II Hypersensitivity reaction, __________ is involved.

(a) IgM antibody (b) IgG antibody

(c) IgE antibody (d) IgG and IgM antibodies

12. •ußø© Bµ®£ ÷Põhõß G¢u Aª÷Úõ Aª»zøu JzxÒÍx ?
(A) «zv÷¯õøÚß (B) Áõø»ß
(C) I÷\õ¼²]ß (D) BºâøÚß
The principal start codon corresponds to which amino acid ?

(a) Methionine (b) Valine

(c) Isoleucine (d) Arginine

For more Question Papers, Sample Papers, Notes & Syllabus visit Page 4 of 8

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13. ö£õ¸zxP :

(1) ìøhø£÷»õPõUPì B›¯ì (i) \[Q¼z öuõhº
(2) ìmöµ¨÷hõPõUPì ø£÷¯õãßì (ii) i¨÷ÍõPõUøP
(3) ø|^›¯õ ö©Ûßöáiì (iii) P©õ ÁiÁ®
(4) ¨›÷¯õ Põ»÷µ (iv) vµõmø\ öPõzx
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(A) (1) - (ii), (2) - (iii), (3) - (iv), (4) - (i)

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(1) - (i), (2) - (ii), (3) - (iii), (4) - (iv)

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(1) - (iii), (2) - (iv), (3) - (i), (4) - (ii)

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(1) - (iv), (2) - (i), (3) - (ii), (4) - (iii)

Match :

(1) Staphylococcus aureus (i) arranged in chains

(2) Streptococcus pyogenes (ii) diplococci

(3) Neisseria meningitidis (iii) comma shaped

(4) Vibrio cholerae (iv) bunch of grapes

(a) (1) - (ii), (2) - (iii), (3) - (iv), (4) - (i)

(b) (1) - (i), (2) - (ii), (3) - (iii), (4) - (iv)

(c) (1) - (iii), (2) - (iv), (3) - (i), (4) - (ii)
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(d) (1) - (iv), (2) - (i), (3) - (ii), (4) - (iii)

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14. TØÖ (A) u߸®¤ PõØÔÀ»õ _Áõ]PÒ PõØÓØÓ `Ì{ø»°À ö|õvzu¾®
:

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TØÖ (B) ö|õvzu¼À ø£¸ÂU Aª»® £À÷ÁÖ P›© Aª»©õP
:

©õØÓ¨£kÁuß ‰»® «sk® BP BUêá÷ÚØÓ® NADH NAD
+

AøhQÓx.
(A) TØÖ (A) uÁÖ, (B) \›.
(B) TØÖ (A) ©ØÖ® (B) Cµsk® \›.
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(C) TØÖ (A) ©ØÖ® (B) Cµsk® uÁÖ.
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las carry out aerobic respiration when oxygen is present.

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various organic acids.
+
by converting pyruvic acid into

(a) Statement (A) is false, (B) is true.

(b) Both Statement (A) and (B) are true.

(c) Both Statement (A) and (B) are false.

(d) Statement (A) is true, (B) is false.

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9062 6

15. R÷Ç öPõkUP¨£mkÒÍ öuõÈÀ~m£zvÀ Cµshõ® ÷uºÄ •øÓUS
ö£õ¸zu©õÚx Gx ?
(A) ö\ÔÅmhÀ Áͺa] öuõÈÀ~m£®
(B) Tmk umk öuõÈÀ~m£®
(C) ö£›¯ SÊ öuõÈÀ~m£®
(D) BU÷éõ÷ÚõQµõ¤
Which among the following is appropriate for secondary screening method ?

(a) Enrichment culture technique

(b) Crowded plate technique

(c) Giant colony technique

(d) Auxanography

£Sv & II / PART - II

SÔ¨¦ : GøÁ÷¯Ý® BÖ ÂÚõUPÐUS Âøh¯ÎUPÄ®. ÂÚõ Gs 24 &US
Pmhõ¯©õP Âøh¯ÎUPÄ®. 6x2=12

Note : Answer any six questions. Question No. 24 is Compulsory.

16. PCM &Cß TÖPÒ £ØÔ GÊxP.
Write the components of PCM.

17. SøÓ¢u£m\ £õUj›]hÀ ö\ÔÄ (MBC) Áøµ¯Ö .

Define - The Minimal Bactericidal Concentration (MBC).

18. ÷PßPº Áøµ¯ÖUPÄ®.
Define Chancre.

19. öẮ SÇõ´ Áøµ¯ÖUPÄ®.
Define Germtube.

20. Bº÷£õ øÁµì £ØÔ ]Ö SÔ¨¦ GÊxP.
Give a short note on the Arbo Virus.

21. PhzvPÒ GßÓõÀ GßÚ ? GkzxUPõmkPÒ u¸P.
What are vectors ? Give examples.

22. EnÂß ‰»® £µÄ® £õUj›¯À ÷|õ´PÒ CµsiøÚ GÊxP.
Write any two bacterial food borne disease.

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23. £õµõiÛU ¸¢÷uõ®¤ GßÓõÀ GßÚ ?
What is Paratenic host ?

24. H÷uÝ® Cµsk ©µ£q ö£õ¸Ò Phzx® •øÓPøÍ GÊxP.
Write any two methods of gene transfer.
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g l
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g a 6x3=18

Note :
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Answer any six questions. Question No. 33 is Compulsory.

25. ¦Ñµ\sm ~s÷nõUQ°ß £¯ß£õkPøÍ _¸UP©õP GÊuÄ®.
Write a brief account on the application of fluorescent microscopy.

26. E- ÷\õuøÚ £ØÔ ]Ö SÔ¨¦ GÊxP.
Write short notes on E-test.

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27.

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Write the differences between Catabolism and Anabolism.

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EnÂÀ ~sq°›PÎß ‰»[PøÍ
List out the sources of micro-organism in food.

29. £õv ö\¯ØøP¯õÚ ö£Û]¼ß GßÓõÀ GßÚ ? GkzxUPõmk u¸P.
What is semi-synthetic penicillin ? Give an example.

30. i¨w›¯õÂØS ÷©ØöPõÒЮ ÷|õ´ uk¨¦ £ØÔ GÊxP.
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Write the prophylaxis for Diphtheria.

31. om GvºÂøÚ £ØÔ GÊxP.
c. Bºuì e m
em Write about Arthus reaction.
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ag PõìªmPøÍ ÂÍUQ AÁØøÓ £¯ß£kzxÁuõÀ ÂøͲ®
32.

Explain Cosmids. Write the advantages of using it.

33. ½è÷©Û¯õ ÷hõ÷ÚõÁõÛ°ß ¨÷µõ÷©ìi÷Põm ©ØÖ® H÷©ìi÷Põmiß £h®
Áøµ¢x £õP[PøÍ SÔUPÄ®.
Draw and label the Promastigote and Amastigote of Leishmania donovani.

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9062 8

£Sv & IV / PART - IV

SÔ¨¦ : AøÚzx ÂÚõUPÐUS® Âøh¯ÎUPÄ®. 5x5=25

Note : Answer all the questions.

34. (A) ÷©õ÷ÚõS÷ÍõÚÀ Bßi£õiPÒ £ØÔ Â›ÁõP GÊxP.
AÀ»x
(B) ]m›U Aª» u¯õ›¨¤À EÒÍh[Q¯ £i{ø»PøÍ ÂÍUSP.
(a) Explain in detail about monoclonal antibodies.

OR

(b) Explain the steps involved in citric acid production.

35. (A) ìøhø£÷»õPõUPì B›¯éõÀ EØ£zv ö\´¯¨£k® |a_PÒ ©ØÖ®
ö|õvPÎß ö£¯ºPøÍ GÊv ÂÍUSP.
AÀ»x
(B) ÷µ¥ì øÁµì &ß Aø©¨ø£ £hzxhß ÂÍUSP.
(a) Name and explain the toxins and enzymes produced by Staphylococcus aureus.

OR

(b) Explain the structure of Rabies virus with diagram.

36. (A) C.G®.¤ ÁÈzuh® £ØÔ ÂÍUSP.
AÀ»x
(B) îì÷hõ¤Íõì÷©õ]ì &ß ©¸zxÁ A®\[PøÍ Â›ÁõP ÂÁ›UPÄ®.
(a) Explain about EMP Pathway.

OR

(b) Elaborate on clinical features of histoplasmosis.

37. (A) ^u÷£v ©ØÖ® A«¤U ÷£vUS® Cøh÷¯ EÒÍ ÷ÁÖ£õmøh AmhÁøn¨
£kzxP.
AÀ»x
(B) &ø¯¨ £¯ß£kzv i.Gß.H xskPøÍ ö£¸UP GßöÚßÚ ö£õ¸mPÒ
PCR

÷uøÁ¨£kQßÓÚ ?
(a) Tabulate the difference between bacillary dysentery and amoebic dysentery.

OR

(b) What are the materials needed to amplify a segment of DNA using PCR ?

38. (A) ¥ÚõÀ ÷PõG¤ö\ßm ÷\õuøÚø¯ ÂÍUSP.
AÀ»x
(B) EnÄPÎß ÁøP¨£õmiøÚ ÂÁ›UPÄ®.
(a) Explain phenol coefficient test.

OR

(b) Describe classification of food.

- o O o -

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