KUET 2022 Question Paper M.Sc. Clinical Biochemistry

FOR KUET EXAM PREPARATION

KUET 2022
Question Paper · M.Sc.
Clinical Biochemistry
EXAM YEAR TYPE SUBJECT

KUET 2022 Question Paper M.Sc. Clinical Biochemistry

Notes · Sample Papers · Previous Year Papers · Mock Tests

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ENTRANCE TEST-2022
SCHOOL OF' BIOLOGICAL SCIENCES

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CLINICAL BIOCHEMISTRY
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Question Booklet Se.i". I
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Total Questions : 60
TimeAllowed
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70 Minutes Roll No. :

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Instructions for C&ndidates :

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frll upathe necessary information in the
1. Write your Entrance Roll Number in the
Test provided tie top ofthis
provided
space of Question Booklet
the OMRAnswer Sheet
spaces
at
on
page

2. OMRArswer Sheet has an Original Copy and a Candidate's Copy glued beneath it at the top. wlile
making entries in the Odginal Copy, candidate should ensue that the two copies are aligned properly
so tha,the enhies made in the Original Copy against each item are exactly copied in the Candidate's
coPY'

3. All entdes in the OMRAnswer Sheet, including answers to questions, are to be recorded in the Original
Copyonly.

m among th€ options A, B, C and D and
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4. Choose the cofiect / most appropriate response for each question

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darken the circle ofthe appropdate response completely. The incomplete darkened circle is not correctly

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read by the OMR Scanner and no complaint to this effect shall be enEnajned

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5. Use only blue/black ball point pen to darken the circle of conecVmost appropriate response. ln no case
a
gevink pen or pencil should be used.
6. Do not darken more than one circle ofoptions for any question. A question with more than one darkened
response shall be considered wrong.

7. There will be 'Negative Marking' for wrong answers. Each.rvrong answer will lead to the deduction
of0.25 marks fiom the total score ofthe candidate.
8. Onlylhose candidates who would obtain positive score in Entrance Test Examination shall be eligible
IOr aomlsslon.

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9. Do not make any stray mark on the OMR sheet.
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10. Calculators and mobiles shall not be pemitted inside the examination hall.

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11. Rough work, ifany, should be done on the blank sheets provided with the question booklet.

las 12. must handled carefully
Sheet be it should not
a g and it
be or case

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will not be evaluated.

Enswe that your OMR Answer
13. has been signed by the Invigilator and the candidate himself/
Sheet
herseli
14. At the end ofthe examination, hand over the OMRAnswer Sheet to the invigilator who will first tear off
the original OMR sheet in presence ofthe Candidate ar-d hand over the Caldidate's Copy to the candidate.
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1. Which ofthe following compound contains botli 7, The deficiency of vitamins that are responsible
ionic and covalent bonds ? for causing scuny and pellagra are :
(A) Methane (A) Ascorbic acid and Riboflavin
(B) Hydrogen (B) Ascorbic acid and Thiamine
(C) Potassium cyanide
(C) Ascorbic acid and Niacin
(D) Potassium chloride
(D) Pantothenic acid and Niacin
2. The subsrance that can act as both oxidizing as
well as rcducing agent is : 8. The complete biologically active conjugated
(A) NNOI enzyme is called :

(B) NaNq (A) Holoenzf,me
(C) NarSrO3 (B) Coen4me
(D) Na,O, (C) Simpte enzrme
l. Which one of the following interactions is the
(D) Apoenzl'Ine
weak and non-specific athactive force ?
9' Enz),rnes are sensitive to pH. This pH dependence
(A) Ionic interactrons
is due to :
@) Hydrophobicinteractions
(C) Covalentinteractions (A) The structure ofthe active site
(D) van der Waals interactions (B) The structwe ofthe enztme
4. The amino acid that has the laryest number of (C) Presence ofthe charged amino acids at the
rotatable bonds in side chain is : active site
(A) T)rosine (D) Shape and size ofthe enzyme
(B) Proline 10. The inhibitor that binds only to t}e enzyme
(C) Histidine substrate complex is called :
(D) Lysine
(A) Competitiveinhibitor
5. Which ofthe following are called non-sugars ?
(B) Non-Competitive inhibitor
(A) Polysaccharides
(B) Disaccharides (C) Un-Competitiveinhibitor
(C) Monosacchaddes (D) None ofthe above
(D) Oligosaccharides ll. Number of CO, and NADH molecules released
6. The carboxyl group ofeach fatty acid is joined to dudng the Krebs cycle is :
glycerol through a : (A) 3 COrand 2 NADH
(A) Hy&ogenbond (B) 2 CO, and 3 NADH
(B) Covalentbond
(C) l COr and 2NADH
(C) Ionic bond
(D) van der Waals inleractions @) 1 CO, and 3 NADH

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t2. Hemoly'tic anemia is caused by the deficiency of 16. Which one ofthe following glucose transporters
which ofthe following enzymes ? is present on the erythroc)'te membrane ?

(A) Glucose-6-phosphate dehydrcgenase (A) GLUI-I
(B) GLUr-2
(B) 6-phosphogluconate dehydrogenase
(c) GLUI-3
(C) d-ketoglutaratedehydrogenase (D) GLUr-s
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(D) Succinatedehydrogenase

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t'7. The signal sequence of the protein is cleaved by

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13. p-oxidation ofpalmitic acid (16 carbons) is a signal peptidase in which ofthe following cell

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organelles ?

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Palmitoyl COA + TCOA + TFAD + TNAD + 7H,O -+

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(A) Golgi apparatus
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Forthe oxidation ofthis 16-ca6on atom fatty aci4

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(B) Cytosol
complete reaction is :
(C) Endoplasm Reticulum lumen
(A) 6 acetyl COA+ TFADII, + TNADH + TII2O
(D) Mitochondria
(B) 8 acetyl COA+ TFADI! + 8NADH + 8iIrO
18. The stage at which the kinetochore spindle fibers
(c) 8 acetyl coA F TFADIL + TNADH pull the two kinetochores towards the opposite
(D) s aietyl COA+ TFAD4 + TNADH + 6110 poles is

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(A) Metaphase
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14. The enzlme that is deficient in children having

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(B) Prophase
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Lesch-Nyhan S;,ndrome is :

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(A) Hypoxanthine-guanine phosphoribosyl-
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tiansferase
(D) Anaphase
19. The major fearures of B-form ofDNA are :
(B) Adenine phosphoribosyl transferase
(A) The two long polynucleotide stands are
(C) Purinenucleosidephosphorylase
coiled around a central axis
(D) Ribonucleotide reductase (B) Both the stands are wrapped in a right
15. The modem cell theory includes : handed helix

(A) That the cell is the sauotuml and fi.rnctional (C) The strands are antiparallel
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unit oflife (D) None ofthe above
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(B) That all cells arise ftom the pre-existing 20. The enzlme that is primarily utilized for DNA

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repairing and filling of gaps during replication

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cells

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and repair process is :

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(C) Energy flow occurs within cells and alt the
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(A) DNA polynerase I
known living things are made up ofone or
(B) DNA polynerase II
more cells
(C) DNA polymerase III
(D) All ofthe above
(D) All ofthe above

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21. Inbackdat promoter, the -10 and -35 rcgions has 27. The term antibodies
was given bY
a consensns sequence of: (A) Etulich and Metchnikoff
(A) TTTAC, TTGATA (B) Karl Landsteiner
@) TTCCAA, TTCGAA
(C) EmilvonBehring
(C) TATAAT, TTGACA
(D) TTGGCA, CCGGCG (D) Louis Pasteur
22. The Shine Dalgamo sequence is complementary 28 Choose the corect match of the following
to a region at the 3' end of: antibodies :
(A) 2ssrRNA a. lgA 1. Basophils
(B) l6StRNA
(c) 23S!RNA b. IeE 2. Healy chain
@) 5STRNA c. IgG 3. Secretory component
23. The characteristic features of prokaryotic d. ICM 4. Pentamer
organisms are :
5. Crosses placenta
(A) The true membrane bound nucleus is absent
(B) DNA complexed with histones is absent (A) a-5, b-4, c-3, d-l
(C) Mitosis and meiosis absent (B) a-3, b-1, c-5, d-a
(D) All ofthe above (C) a-2, b-3, c-5, d-l
24. Peptidoglycan is a polymer containing two (D) a-5, b-4, c-1, d-2
sugar derivates N-acetylglucosamine and
N-acetylmwamic acidthat are j oined through : 29. Exogenous antigens bind to which class ofMHC '
(A) q-1,4 glYcosidic bond molecules :
(B) P-1,4 glYcosidic bond (A) MHc-l
(C) P-1,6 glYcosidic bond
(B) MHC-II
(D) a-1,6 glYcosidic bond
25. The nature ofnucleic acid in coronavirus is : (c) MHC-I
(A) dsDNA (D) All ofthe above
(B) dsRNA 30. A patient with a disease produces autoantibodies
(C) ssRNA against the acetylcholine rcceptols present on the
(D) ssDNA motor end plates ofmuscles is having :
i6. Puromycin an antibiotic inhibits protein st'nthesis
by binding to : (A) Craves' Disease
(A) A site ofribosome (B) Systernic Lupus ED4hematosus
(B) P site ofribosome (C) Multiple Sclerosis
(C) E site ofdbosome
(D) Myasthenia Gravis
(D,; None ofthe above
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as 31. Mendal chose the garden pea for his experiments 36. ag coirect
Choose the match ofsome phamaceutical

because : recombinant human proteins expressed in
(A) Garden pea is easy to cultivate and short transgenic plants :

life cycle P Tobacco and
(B) Bisexual flowers and discreated characters sunflower plant l. SerumAlbumin
(C) Self-fertilization and easyhybridization
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(D) All ofthe above
m of genes occu$ due to . c o
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potato plant 2. Cnorth hormone

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32. Independent assortment R fuce plant
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3. Epidermal gro*h

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orientation
the ofchJomosomes at
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factor

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(A) Metaphase of mitosis
S. Tobaccoplant 4. Alpha-interferon
(B) (A) P-4, Q-3, R-2, S-1
(C) Metaphase II ofmeiosis
(B) P-2, Q-1, R-4, s-3
(D) All the phases ofthe cell division
(c) P-1, Q- 2, R-3, s-4
Crossing over takes place in which phase ofthe
(D) P-3, Q-2, R-4, S-1
gophase I stage of meiosis ?

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37. Potrykus and Beyer developed genetically

(A) l.€ptotene
engineered rice kno'wn as golden rice rich in :

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(B) Zygotene

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(A) \ltamin D
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(C) Pachlaene
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(D) Diplotene
(C) Vitamin C
34. The nucleotide sequence in the telomeres of
vedebntes is :
(D) VitaminA
(A) CCCTAA 38. Which of the following techniques are used to
transfer DNA into the host cell ?
(B) TTTCTT
(c) cccAGG 1. Electroporation

3. Sonication .com
(D) TTAGCG 2. Tmnsformation
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35.

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4. Transfection
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ofthe pyrimidine residues is
end

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(A) 1,2,3
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(A) RNaseA
(B) RNase H (B) 2,3 and 4 only
(C) Mung bean nuclease (C) I and 2 only
(D) Si nuclease (D) 1,3 and 4 only
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39. The end product of the thylakoid reactions are 44. The three-dimensional images of the surface of
the high energy compounds in the form of : the cells and tissue can be visualized by

(A) ADP andNADP. (A) Scanning electon miqoscope
(B) ATPandNADPH (B) Fluorescencemiqoscope
(C) ADP andNADPH (C) Compoundmicroscope
(D) Transmission electlorl nicroscope
(D) ATPandNADP-
45' The molecular mass of the smallest molecules
40, Photorcspiration takes place in which ofthe three
unable to penetrate the pores of a cell is called :
organelles ofthe plant cell ?
(A) Void volume
(A) C)'tosol, clforoplast, mitochondria
(B) Exclusion limit
(B) Golgi appamtus, chloroplast, mitochondria (C) Bed volume
(C) Chlorcplast, peroxisomes, mitochondda (D) htemal volume
(D) Noneoftheabove 46. The forces dnt effect the biomolecules to sedimelt
41. The corect sequence for the linear electron flow at the bottom ofthe tube is :
in plants is : (A) Force ofbuoyaacy
(A) PSII, q,tochrome b6fcomplex and PSI (B) Force offtiction
(B) PSI, PSII and cltochrome b6fcomplex (C) Centrifugal force
(C) PSl, c).tochlome b6fcomplex and PSII (D) All ofthe above
(D) C]'tochomeb6fcomplex, PSII and PSI 47 Which nephron process is the least selective ?

The amino acid methionine is the precrrsor of (A) Reabsorption
which ofthe following plant hormones ? (B) Active tlansport
(A) Gibberellins (C) Salt pumping by the loop ofHenle
(B) Abscisic acid (D) Filtation
(C) Cl,tokines 48' Which of the following is not an accurate
statement ?
(D) Ethylene
(A) Hormones are chemical messengers that
Sodium dodecyl sulphate is used to separate travel to target cells though the circulatory
proteins by PAGE because : system
(A) It increases the solubility ofproteins (B) Hormones are seqeted by specialized cells
(B) It gives the uniform negative charge to the usually located in endocrine glands
proterns (C) Hormones of the same chemical class
(C) Inqeases stability ofproteins usually have the same function

(D) It d€creases the suface tension ofthe bufl€r (D) Hormones often regulate homeostasis
tlrough antagonistic flrnctions
used in electrophoresis

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Which ofthe following statements is not true ?
the concentation of :
(A) An antigen can have different epitopes
(A) Carbonmonoxideintheblood (B) An antibody has more than one antigen_
(B) Carbon dioxide in the blood binding site
(C) Oxygen in the blood (C) A pathogen makes more than one antigen
(D) Carbonic acid in the blood (D) A l),mphoclte has receptors for multiple

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50. Which of the following is rlot a pdmary activity different antigens

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56. Following emigration from blood vessets,
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leucoc)ie migration to the site ofinfecdon or inju-ry

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(A) Mechanicaldigestion

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is mediated by :

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(B) Nuhient absorption
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(A) Prostaglandins
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(D) Mucusa seqetion
(C) En4me secretion (B) Histanine
(C) Bradykinin
51. Thyroid hormone,s metabolic role includes : (D) Chemokines
(A) Deqeased oxygen consumption 57. Regarding Chronic inflammation, which is
(B) Increased lipogenesis conect ?

(C) IncreasedLipolysis (A) It is chaxacterised by h;peraemia, oedema,
and leukoctte infi ltration
(D) Protein A_nabolism
mpathways neutrophils
(B) Monocytes use the same chemotactic
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.c(C) It always prcceded
52. Which ofthe following does not describe a
thl,roid as

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hormone's metabolic function ?
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inflamnatron
by acute

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(A) Clycogenolysis (D)
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Most frequently results in resolutiorr

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(B) Gluconeogenesis is a sign of inflammation ?
(C) Glucose oxidation (A) Calor
(D) Glycogenesis (B) Dolor
53. The black colour of urine rs caused by the (C) Rubor
presence of : (D) All ofthe above
(A) Inflammation 59. V* decreases arld K remains constant is an
example of :
(B) Creatinine
(B) Uncompetitiveinhibition m
(A) Competitiveinhibition

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(C) Alkaptonwia
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(D) Pus cells (C) Non-competitive inlfbition

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54. OGTT test is more sensitive than fasting blood
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60. The molecule which does not exhibit dipole

ag (B) Serumprotein
momenl $ :
(A) Nq
(C) Hbalc (B) CHCI3
(D) Serum protein (c) rlo
{D) CCl4
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