NIPER JEE 2023 Question Paper

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NIPER JEE 2023
Question Paper
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NIPER JEE 2023 Question Paper

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answers provided are tentative and prepared for practice purposes
differences from the actual exam. Users are advised to verify answers from official sources.

1. Cannizaro reaction gives which of the following products?
(a) Ketone and aldehyde (b) Acid and alcohol
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(c) Alcohol and ester (d) Acid and amide
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Correct Answer : (b) Acid and alcohol
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2. The Rh in
(a) Anti-A (b) Anti-B
(c) Anti-D (d) Anti-H
Correct Answer : (c) Anti-D

3. What is not true about Neprilysin inhibitor?
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(a) Sacubitnl is neprilysin inhibitor
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(b) It blocks the breakdown of natriuretic peptides, angiotensin I and bradykinin
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(c) Omapatrilat is pure neprilysin inhibitor
(d) Neprilysin inhibitors can be used with AT11 receptor antagonist
Correct Answer : (c) Omapatrilat is pure neprilysin inhibitor

4. Which one of the following guidelines is followed for analytical method validation, if
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the method of analysis is not official in any pharmacopoeia or appears in other

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5. What is the long form of DSMB?
(a) Direct Server Message Block
(b) Data Safety Monitoring Board

(c) Diagnostic and Statistical Manual Board NIPER JEE 2023 Question Paper

(d) DigitalShow MultimediaBroadcasting
Correct Answer : (b) Data Safety Monitoring Board

6. The volume of distribution equals _________ divided by initial drug concentration:
(a) Clearance (b) Initial drug concentration
(c) Half-life (d) Dose
Correct Answer : (d) Dose

7. Two daughter cells are formed in mammals by:
(a) Mitosis (b) Meosis
(c) Cytokinesis (d) Binary fusion
Correct Answer : (a) Mitosis

8. Fluorine is:
(a) H bond donor
(b) H bond acceptor
(c) Either donor or acceptor based on the atom to which it is attached
(d) Neither donor nor acceptor due to anomalous behavior
Correct Answer : (b) H bond acceptor

9. Numbers of nitrogens in capreomycin are:
(a) 10 (b) 12
(c) 14 (d) 16
Correct Answer : (c) 14

10. When the velocity of enzyme activity is plotted against substrate concentration,
which of the following is obtained? https://www.pyqonline.com
(a) Rectangular hyperbolic curve (b) Straight line with positive slope
(c) Sigmoidal curve (d) Parabolic curve
Correct Answer : (a) Rectangular hyperbolic curve

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11. Which of the process in with respect to emulsion stability
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(a) Cracking (b) Creaming
(c) Deflocculation (d) Coalescence
Correct Answer : (b) Creaming

12. The organometallic reagents act as:
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(a) nucleophiles towards the (b) electrophile towards the
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electrophilic carbonyl group nucleophilic carbonyl group
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(c) free radicals towards the (d) monodentate ligand towards
gl a
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electrophilic carbonyl group carbonyl oxygen
Correct Answer : (a) nucleophiles towards the electrophilic carbonyl group

13. Phocomelia means:
(a) Defect in development of long (b) Defect in development of spine and
bones spinal cord
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(c) Deposition of cartilage on bones
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(d) Defect in development of sensory

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organs

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Correct Answer : (a) Defect in development
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14. Application for license to manufacture drugs other than those specified in the
Schedules C and C(1) shall be made to the Licensing Authority of the State in:
(a) Form 24B (b) Form 24
(c) Form 24F (d) Form 24D
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Correct Answer : (b) Form 24
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(c) D amino acids (d) S amino acids
Correct Answer : (b) L amino acids

16. Which one of the following methods cannot be used to determine the secondary
structure content of a protein?
(a) Circular dichroism spectroscopy (b) Fourier transform infrared
spectroscopy
(c) Mass spectrometry (d) X-ray crystallography
Correct Answer : (c) Mass spectrometry

17. In relation to Ayurvedic, Siddha or Unani drug, an Inspector appointed by the
Central Government or a State Government under which section of D& C Act 1940
Rules 1945? https://www.pyqonline.com
(a) 20 (b) 21
(c) 33F (d) 33G
Correct Answer : (d) 33G

18. Which of the following statement is not true about pH partition theory?
(a) It explains the influence of GI pH and drug pKa on the extent of drug transfer or
drug absorption
(b) The ratio of non-ionized to ionized drug at any pH may be calculated from the
Henderson-Hasselbalch equation.
(c) The unionized form of the ionizable drug is absorbed
(d) The unionized form of the unionizable drug and ionized form of the ionizable drug
is absorbed in cell.
Correct Answer : (d) The unionized form of the unionizable drug and ionized form of
the ionizable drug is absorbed in cell.

19. Introduction of foreign genes into plant cells can be carried out using all except:
(a) Agrobacterium
(b) CaCl2 mediated plasmid uptake
(c) Electroporation
(d) Gene gun
Correct Answer : (b) CaCl2 mediated plasmid uptake

20. Which of the following reactions is not involved in solid phase peptide synthesis?

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(b) Coupling
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(c) Cleavage
Correct Answer : (d) Cyclization

21. True about tautomeric forms of a drug are all of the following except:
(a) Tautomers are different (b) Tautomers differ in position of
compounds. atoms (usually hydrogen).
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equilibrium with other.
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Correct Answer : (d) Tautomers cannot be isolated.
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22. Which group is added to the substrate during the Vilsmeier-Haack reaction?
(a) Formyl (b) Amino
(c) Alkyl (d) Hydroxyl
Correct Answer : (a) Formyl

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(a) Antithyroid (b)
(c) Antidiabetic ag
Correct Answer : (a) Antithyroid

24. The units for clearance are:
(a) concentration/half-life

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(c) time/dose
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25. Which of the following compounds will show highest absorption in IR spectrum for
carbonyl group?
(a) Formaldehyde (b) Acetone

(c) Benzaldehyde (d) Cinnamaldehyde NIPER JEE 2023 Question Paper

Correct Answer : (a) Formaldehyde

26. Which shift is observed with increase in conjugation?
(a) Bathochromic (b) Hypsochromic
(c) Hyperchomic (d) Hypochromic
Correct Answer : (a) Bathochromic

27. When two variables are compared, which parameter will help to predict future
outcome of forecasting:
(a) Regression (b) Correlation
(c) Covariance (d) Standard deviation
Correct Answer : (a) Regression

28. Hard Lewis acids have:
(a) High positive charge & easy to (b) Low energy LUMO but large
polarize & oxidize magnitude LUMO coefficient
(c) High positive charge & strongly (d) Electron pair in their valence shell
solvated
Correct Answer : (c) High positive charge & strongly solvated

29. The chemical shift region in PMR for vinylic protons is:
(a) 0-1.5 (b) 1.5-2.5
(c) 4.5-6.5 (d) 9.0-12.0
Correct Answer : (c) 4.5-6.5

30. Which compound will show maximum IR absorption frequency?
(a) Acetone (b) Methyl ethyl Ketone
(c) Cyclobutanone (d) Methyl Vinyl Ketone
Correct Answer : (c) Cyclobutanone

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(c) Quartile Deviation (d) All of the above
Correct Answer : (b) Standard Deviation

32. Precision of an analytical method for assay of drugs in formulation within
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(c) Robustness
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Correct Answer

33. Which of the following statements is correct?
(a) Sumatriptan- 5HT1A agonist
(b) Buspirone- 5HT10 agonist

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(c) Cisapride- 5HT4 agonist
(d) Ketanserin- 5HT3 agonist
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Correct Answer : (c) Cisapride- 5HT4 agonist

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34. Toxicity of digoxin may be exacerbated by which of the following?
(a) Hypocalcaemia (b) Hyperkalaemia
(c) Hypomagnesaemia (d) Hyperuricaemia
Correct Answer : (c) Hypomagnesaemia

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35. Mutarotation involves:
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(b) Conformational inversion
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(d) Diastereo isomerization
a Correct Answer : (d) Diastereo isomerization

36. 127, 131, 139, ?, 151, 157, 163, 167 identify number at ?
(a) 149 (b) 147

(c) 141 (d) 143 NIPER JEE 2023 Question Paper

Correct Answer : (a) 149

37. Which of the following compound will give a white precipitate with alcoholic
AgNO3 solution?
(a) Allyl chloride (b) Chloro benzene
(c) Vinyl benzene (d) Vinyl chloride
Correct Answer : (a) Allyl chloride

38. Which among the following reactions is suitable for isolation of isocynate in pure
form?
(a) Beckmann rearrangement (b) Curtius rearrangement
(c) Hofmann rearrangement (d) Fries rearrangement
Correct Answer : (b) Curtius rearrangement

39. Cope elimination occurs via:
(a) E1 elimination followed by E2 (b) E2 elimination followed by E1
elimination elimination
(c) Intramolecular, syn-selective (d) E2 elimination with neighboring
sigmatropic reaction group assistance
Correct Answer : (c) Intramolecular, syn-selective sigmatropic reaction

40. Synonym of Furious:
(a) Enraged (b) Elated
(c) Placid (d) Fast
Correct Answer : (a) Enraged

41. Which among the following is used as a free radical initiator?
(a) Benzoyl peroxide (b) KI
(c) CH33I (d) Nitrobenzene
Correct Answer : (a) Benzoyl peroxide

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(a) Porphyrin
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(c) Corrin (d) Heme
Correct Answer : (c) Corrin

43. Which country is known as The land of thousand lakes?
(a) Finland (b) Rawanda
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(c) Indonesia
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a of straight lines obtained by joining 16 points on a plane, no twice of
44. The number
them being on the same line is:
(a) 120 (b) 110
(c) 210 (d) None of these
Correct Answer : (a) 120

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45. National voters day is celebrated on:
(a) January 12
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(c) October 31
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Correct Answer : (b) January 25

46. Which of the following is not true for student t-test?
(a) It compares two groups to see if their means differ
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47. A double-stranded DNA molecule that has 22% guanine will have:
(a) 22% thymine (b) 28% cytosine
(c) 28% adenine (d) 22% uracil

Correct Answer : (c) 28% adenine NIPER JEE 2023 Question Paper

48. Which of the following is a disease of myelin sheath?
(a) Polio (b) Multiple sclerosis
(c) Leprosy (d) Alzheimer
Correct Answer : (b) Multiple sclerosis

49. Baljet test is used of detection of:
(a) Cardiac glycoside (b) Flavonoids
(c) Proteins (d) Alkaloids
Correct Answer : (a) Cardiac glycoside

50. What should be the frequency to conduct HEPA filter integrity test?
(a) Minimum once every year (b) Minimum once two years
(c) Minimum once three years (d) Depends on use of HEPA
Correct Answer : (a) Minimum once every year

51. The book Not just an accountant is written by:
(a) Raghuram Rajan (b) Vinod Rai
(c) Urjit Patel (d) Amartya Sen
Correct Answer : (b) Vinod Rai

52. Synonym of Adduce:
(a) Add (b) Cite
(c) Hide (d) Screen
Correct Answer : (b) Cite

53. Antonym of Abundance:
(a) Plenty (b) Plethora
(c) Profusion (d) Dearth
Correct Answer : (d) Dearth

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54. Proteins can be analyzed by UV spectroscopy because the
show absorption: a
(a) Tryptophan and tyrosine (b) Lysine and valine
(c) Leucine and isoleucine (d) Methionine and cysteine
Correct Answer : (a) Tryptophan and tyrosine

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55. Which of the following proton exists more down filed in NMR spectrum?
(a) Saturated .co (b) Aromatic
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(c) Vinylic (d) Allylic
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Correct Answer

56. Which of the following contains anthocyanin pigments?
(a) Tomato (b) Grapes
(c) Beet root (d) Potato

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Correct Answer : (b) Grapes

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57. The ratio of the energy absorbed to a
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the total incident energy is called as:
(a) Reflectivity ag (b) Transmissivity
(c) Absorptivity (d) Conductivity
Correct Answer : (c) Absorptivity

58. The Cartagena Protocol regulates trade in:
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(a) Endangered species of plants and (b) Genetically modified organisms
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animals
s e
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59. The most frequently occurring value in a data set is called:
(a) Mean (b) Median
(c) Mode (d) Range

Correct Answer : (c) Mode NIPER JEE 2023 Question Paper

60. Geometrical isomerism is shown by:
(a) Maleic acid (b) Malic acid
(c) 1-Butene (d) Tartaric acid
Correct Answer : (a) Maleic acid

61. In hybridoma technology, which one of the following enzymes is absent in the
myeloma cells that are used for monoclonal antibody production?
(a) Hypoxanthine-guanine phosphoribosyltransferase
(b) Alanine aminotransferase
(c) Triose phosphate isomerase
(d) Glycosyl transferase
Correct Answer : (a) Hypoxanthine-guanine phosphoribosyltransferase

62. The muscarinic receptor that couples to G proteins responsible for adenylyl
cyclase inhibition and plays a key role in cholinergic input to the heart is classified as
(a) M1 receptor (b) M2 receptor
(c) M3 receptor (d) M4 receptor
Correct Answer : (b) M2 receptor

63. Identify the compound which shows mass spectrum with m/z values at 156(M,
base peak), 127 and 129.
(a) CH3I
(b) C2H5I
(c) C2H5Br
(d) C2H5Cl
Correct Answer : (b) C2H5I

64. The ring system present in fluconazole is:
(a) Imidazole (b) 1, 2, 3-Triazole

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(d) 1, 3, 5-Triazole
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65. Which of the following contributes C4N building block as heterocyclic ring to
tropane alkaloids?
(a) D-ornithine (b) L-lysine
(c) L-leucine (d) L-ornithine
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Correct Answer : (d) L-ornithine

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66. Which of the
analysis: gl a
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(a) Fluorescence detector (b) Conductometric detector
(c) Refractive index detector (d) UV detector
Correct Answer : (c) Refractive index detector

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67. Which one of the following programs is used for finding distantly related (or
remote) protein homologs?
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(a) BLASTN
s emBLASTX
(b)

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(c) PSI-BLAST
Correct Answer : (c) PSI-BLAST

68. Marketing Authorization Application (MAA) is to be made to the relevant authority
to market a drug or medicine in which country?
(a) US market (b) Europe market
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(c) Canadian market (d) All countries
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Correct Answer : (b) Europe market
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a
a
(a) Serotonin (b) Histamine
(c) Acetylcholine (d) GABA
Correct Answer : (c) Acetylcholine

70. Recently approved drug by FDA, flibanserin, is indicated for the treatment of:

(a) PTSD (Post-traumatic stress (b) STD (Sexually transmitted disease)
disorder)
(c) HSDD (Hypoactive sexual desire (d) PTD (Persistent trophoblastic
disorder) disease)
Correct Answer : (c) HSDD (Hypoactive sexual desire disorder)

71. Which of the following cephalosporin has disulfiram like effect?
(a) Cefixime (b) Cefotetan
(c) Cefuroxime (d) Cefamandole
Correct Answer : (b) Cefotetan

72. For normal distribution, the mean (µ) and standard deviation (s) are:
(a) µ=0, s=1 (b) µ=0, s=0
(c) µ=1, s=1 (d) µ=100, s=10
Correct Answer : (a) µ=0, s=1

73. The term nutraceutical was coined by Dr. Stephen DeFacile in year:
(a) 1979 (b) 1989
(c) 1999 (d) 2009
Correct Answer : (b) 1989

74. Leishmaniasis is transmitted by:
(a) Sand fly (b) Tsetse fly
(c) Rodent fly (d) Mosquitoes
Correct Answer : (a) Sand fly

75. Iontophoresis is employed in which drug delivery system?
(a) Transdermal (b) Epidural
(c) Pulsatile (d) Auricular
Correct Answer : (a) Transdermal

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76. Matrix-M used as an adjuvant in vaccines is obtained from
a
(a) Quillaja saponaria (Soap bark) tree (b) Aesculus hippocastanum (Horse
chestnut)
(c) Glycyrrhiza glabra (Liquorice) (d) None of the above
Correct Answer : (a) Quillaja saponaria (Soap bark) tree

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77. Ebola virus is:
(a) Filovirus .co (b) Arbovirus
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la : (a) Filovirus
(c) Togavirus (d) Retrovirus
g a
a
Correct Answer

78. Which of the following rearrangement proceeds via enamine intermediate?
(a) Willgerodt (b) Favorski
(c) Sommelet (d) Stevensen

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Correct Answer : (a) Willgerodt

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79. Favipiravir inhibits:
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a (b) DNA dependent RNA polymerase
(a) RNA dependent RNA polymerase
(c) Protease (d) DNA dependent DNA polymerase
Correct Answer : (a) RNA dependent RNA polymerase

80. Bedaquiline an antitubercular drug acts by:
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(a) Inhibiting proton pump activity of (b) Inhibiting DNA gyrase
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ATP synthase
s e
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(d) Binding to DNA dependent RNA

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a Correct Answer : (a) Inhibiting proton pump activity of ATP synthase

81. Which of the following organelles does not have membrane?
(a) Ribosome (b) Lysosome

(c) Peroxisome (d) Endoplasmic reticulum. NIPER JEE 2023 Question Paper

Correct Answer : (a) Ribosome

82. What is the sequence of staining steps in Gram staining?
(a) lodine → Crystal violet → Ethanol → (b) Crystal violet → lodine → Ethanol →
Safranin Safranin
(c) Safranin → lodine → Ethanol → (d) Ethanol → lodine → Crystal violet →
Crystal violet Safranin
Correct Answer : (b) Crystal violet → lodine → Ethanol → Safranin

83. Novavax is:
(a) mRNA vaccine (b) DNA based vaccine
(c) Protein based vaccine (d) Inactivated virus vaccine
Correct Answer : (c) Protein based vaccine

84. Alkynes can be fully hydrogenated into alkanes with the help of:
(a) Lindlar's catalyst
(b) Pt/C, H2
(c) NaBH4
(d) LiAlH4
Correct Answer : (b) Pt/C, H2

85. The hybridization of carbons in allene is:
(a) Two terminal carbons are sp2 & central carbon is sphybridised
(b) Two terminal carbons are sp & central carbon is sp2 hybridised
(c) Two terminal carbons are sp3 & central carbon is sp hybridized
(d) Two terminal carbons are sp & central carbon is sp2 hybridised
Correct Answer : (a) Two terminal carbons are sp2 & central carbon is sphybridised

86. Which of the following is not aromatic:
(a) Thiophene (b) Benzene

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(d) Pyrazole
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87. The world's first plant-derived protein based Covid-19 vaccine is:
(a) Sputnik (b) Covishield
(c) Covaxin (d) Cofivenz
Correct Answer : (d) Cofivenz
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88. Quality by design. (QbD) is a concept introduced by the international conference on em
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harmonization s(ICH) l as
(a) ICH Q5 g
la ag
a (b) ICH Q6
(c) ICH Q7 (d) ICH Q8
Correct Answer : (d) ICH Q8

89. A protein without its prosthetic group is known as:
(a) Apoprotein
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(b) Hemoprotein
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(c) Holoprotein
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(d) Lipoprotein
e
Correct Answer : (a) Apoprotein
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90. The interaction of 2-methyl-2-phenyl succinic acid with excess of 40%
methylamine result into which of the following product?
(a) Mephenytoin (b) Methsuximide
(c) Suxamethonium (d) Paramethodione

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Correct Answer : (b) Methsuximide
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g l a
at position:
l a a
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(a) 2 (b) 3
(c) 4 (d) 5
Correct Answer : (a) 2

92. The confirmatory studies are done in which phase of clinical trials?

(a) Phase I (b) Phase II NIPER JEE 2023 Question Paper

(c) Phase III (d) Phase IV
Correct Answer : (c) Phase III

93. Computer understands which language:
(a) Assembly Language (b) Binary Language
(c) BASIC (d) Holographic Language
Correct Answer : (b) Binary Language

94. Which one of the following is a primary lymphoid organ?
(a) Thymus (b) Lymph node
(c) Bone marrow (d) Spleen
Correct Answer : (a) Thymus

95. The equation used for fluid flow through powder bed:
(a) Ergun equation (b) Darcy equation
(c) Hagen-Poisuille equation (d) Burke-Plummer equation
Correct Answer : (b) Darcy equation

96. For gene therapy, which of the following cannot be used as a means of delivery?
(a) Polymers (b) Liposomes
(c) Bacteria (d) Viruses
Correct Answer : (c) Bacteria

97. Lectins are:
(a) Sugar specific to proteins (b) Enzyme specific to carbohydrates
(c) Carbohydrates specific to enzyme (d) Sugar specific to sugar
Correct Answer : (a) Sugar specific to proteins

98. According to IUPAC nomenclature sodium nitroprusside dihydrate is named as:
(a) Sodium pentacyanonitrosylferrate (II)

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(d) Sodium pentacyanonitrosylferrate (III)
a
Correct Answer : (a) Sodium pentacyanonitrosylferrate (II)

99. Which is wrong about Viadur Implant:
(a) Leuprolide acetate
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(b) Biodegradable
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(c) Osmotically-driven miniaturized implant

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100. Identify which of the following pair is diastereomers.

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Correct Answer : (d)

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101. Carmustine and poly[1,3-bis(p-carboxyphenoxy) propane-co-sebacic acid] spray
s e
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dried into particles and compressed into wafers that must be stored at or below -
s g l a
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20ooC to avoid drug precipitation is:
g a
a (b) Viadur
(c) Lacriset (d) Ocusert
Correct Answer : (a) Gliadel

102. Which one of the following figures represents the correct sequence of phases in
adult eukaryotic cell cycle?
(a) S → M → G11 → G2 (b) G 1 → S → G 2 → M
(c) G 1 → G 2 → S → M (d) S → G 1 → M → G 2
Correct Answer : (b) G 1 → S → G 2 → M

103. Protein that helps other proteins to fold correctly is:
(a) Chaperone (b) Proteasome
(c) Ubiquitin (d) Desmosome
Correct Answer : (a) Chaperone

104. Calculate the loading dose of drug (X) when the target concentration is 5 mg/L,
volume of distribution (Vd)is 15 L, and the bioavailability is 30%.
(a) 2500 mg (b) 225 mg
(c) 250 mg (d) 75 mg
Correct Answer : (c) 250 mg

105. The order of saponification of ethylacetate is:
(a) Zero (b) First
(c) Second (d) Pseudo-zero
Correct Answer : (c) Second

106. Which of the following is a triphenylmethane dye?
(a) Methyl orange (b) Indigo
(c) Malachite green (d) Erichrome blac
Correct Answer : (c) Malachite green

107. In chromatography, displacement type pumps are known as:
(a) Syringe pump (b) Reciprocating pump
(c) Pneumatic pump (d) Rotary pump
Correct Answer : (a) Syringe pump

m
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.co s em
em la to antibodies for

s g
108. In ELISA, which of the following enzymes are conjugated
detection of the analyte? a
P. Alkaline phosphatase
Q. Trypsinase
R. Horseradish peroxidase
S. Amylase
(a) P and R (b) P and Q
m
.co
(c) Q and S (d) R and S
m
.co
Correct Answer : (a) P and R
m s e m
a s e g la
a
l of the following plant growth regulators facilitates adventitious root
109. Whichgone
a
formation? https://www.pyqonline.com
(a) Auxin (b) Zeatin
(c) Dihydrozeatin (d) Kinetin
Correct Answer : (a) Auxin

m
.co
110. Which document of the International Conference on Harmonization (ICH)

s em
provides guidelines for the accelerated stability studies?

g la (b) Q7
a (d) Q 14
(a) Q1A (R2)
(c) Q 9
Correct Answer : (a) Q1A (R2)

111. Which of the following sentences is/are true concerning the 1H-NMR spectrum of
deuterated cyclohexane, C6D11?
m
.co
I. The compound exhibits identical spectra at all temperatures.
m
.co m
II. At extremely low temperatures, the spectrum shows one peak, while at high
m s e
s e
temperatures, two peaks are observed
g l a
g l a III. The spectrum is broadest at very high temperatures.
a
a IV. The spectrum becomes broader as the temperature is lowered, eventually splitting
into two narrow peaks.
(a) Only I is true (b) Only II and III are true
(c) Only II and III are true (d) Only IV is true
Correct Answer : (d) Only IV is true

112. Which ofthe following is an aminoether that acts as local anaesthetic?
(a) Dicyclomine (b) Pramoxine
(c) Mepivacaine (d) Eugenol
Correct Answer : (b) Pramoxine

113. Gossypol is a:
(a) Dimer of sesquiterpene aldehyde (b) Optically inactive
(c) Red pigment (d) inhibits several peptidase enzymes
Correct Answer : (a) Dimer of sesquiterpene aldehyde

114. The main polysaccharide constituent of Guar gum is:
(a) Galactomannan (b) Arabinogalactan
(c) Galactoarabinan (d) Glucofructan
Correct Answer : (a) Galactomannan

115. I Do What I Do is the book authored by:
(a) Raghuram Rajan (b) Sachin Tendulkar
(c) Saniya Mirza (d) Narendra Modi
Correct Answer : (a) Raghuram Rajan

116. In India, upto how many years a company can be called as start-up?
(a) 5 years (b) 7 years
(c) 10 years (d) 12 years
Correct Answer : (c) 10 years

117. What is the term of a patent in the Indian system?
(a) 20 years from the date of filing of (b) 14 years from the date of approval
application
(c) 20 years from the date of (d) 14 years from the date of filing of
publication application

m
m
c. o Correct Answer : (a) 20 years from the date of filing of application
m.co
m s e
la

se ag
118. Synonym for Vivid is:
(a) Bright (b) Dull
(c) Shadow (d) Shaded
Correct Answer : (a) Bright

m
m
119. If the rate constants for a drug degradation at temperature 120oC is 1.173/h and
.co
.co
at 140oC is 4.860/h What will be the activation energy of this reaction in this
m s e m
s e
temperature range? (R is 1.987 cal/(mol.K)).
a g la
gl a
a
(a) 23 kCal/mole (b) 28 kCal/mole
(c) 35 kCal/mole (d) 44 kCal/mole
Correct Answer : (a) 23 kCal/mole

120. Tegoserod is:

m
(a) 5HT1 agonist (b) 5HT2 agonist
(c) 5HT3 agonist .co
(d) 5HT4 agonist
m
s e
la
Correct Answer : (d) 5HT4 agonist

ag
121. Upon heating, phthalic acid produces which of the following acid derivative?
(a) An ester (b) A carboxylate
(c) An amide (d) An anhydride
Correct Answer : (d) An anhydride

o m
o mIndian Pharmacopoeia Commission (IPC) is an Autonomous Institution c
. of the
. c
122.
of Health and Family Welfare, Govt. of India is situated at;se
m
m
e (a) Gaziabad
Ministry
l a
las (b) New Delhi a g
ag (c) Chandigarh (d) Chennai
Correct Answer : (a) Gaziabad

123. Which is not true?

(a) Department of Indian System of Medicine and Homoeopathy was formed in 1995

(b) Department of AYUSH was formed in November 2003
(c) Department of AYUSH was formed in November 2014
(d) Ministry of AYUSH was formed in November 2014
Correct Answer : (c) Department of AYUSH was formed in November 2014

124. At whattemperature, both Celsius and Fahrenheit scale read the same value in
degrees?
(a) 100o (b) 130o
(c) -60o (d) -40o
Correct Answer : (d) -40o

125. Which compound has a carbonyl stretch in its IR spectrum at the lowest
wavenumber?
(a) Acetic anhydride (b) Formamide
(c) Cyclohexanone (d) Ethyl acetate
Correct Answer : (b) Formamide

126. If you give 100 mg of a drug that's metabolized by zero-order kinetics at a rate of
10 mg an hour, how much is left in the body the first hour after you give it?
(a) 20 milligrams (b) 40 milligrams
(c) 50 milligrams (d) 90 milligrams
Correct Answer : (d) 90 milligrams

127. Which of the following is not a Histone Deacetylase inhibitor?
(a) Omacetaxine (b) Panobinostat
(c) Romidepsin (d) Vorinostat
Correct Answer : (a) Omacetaxine

128. The powder sample has density of 2.0 g/ml. Experimentally 3.0 g of powder
measured 30 ml in the graduated cylinder. What is the porosity of the powder sample?

m
m
c. o (a) 95 m .co
(b) 85
s e
em a

s (c) 65 (d) 15
g l
Correct Answer : (a) 95
a

129. The reason for presence of weak band at 1750 cm-1-1 in IR spectrum of benzoyl
chloride is:
(a) Inductive effect (b) Fermi resonance between C=O
m
.co
band and first overtone
m
.co
(c) Overtone of =C-H band (d) Conjugation effect
s e m
s em
Correct Answer : (b) Fermi resonance between C=O band and first overtone
g la
g la a
a
130. Piezophiles are type of bacteria that:
(a) Grows best at low water activity (b) Grows optimally between 20° and
45°
(c) Grows at high level of salt (d) Grows optimally at high hydrostatic
pressure
m
.co
Correct Answer : (d) Grows optimally at high hydrostatic pressure

s em
131. In Birch reduction of alkyne usingla
product formed is: a g alkali metals as in liquid NH 3 and alcohol the
3

(a) Anti, cis (b) Anti, trans
(c) Syn, Cls (d) Syn, trans
Correct Answer : (b) Anti, trans

o m
132. White-Vincent method is for:
m . c
c. oIsotonicity calculation
(a)
e m
(b) Molecular weight determination
s
e m l a
l as (c) Particle size determination (d) Viscosity
g
determination
a
ag Correct Answer : (a) Isotonicity calculation

133. A bag contains 5 red balls, 3 green balls, and 2 yellow balls if two balls are drawn
at random without replacement what is the probability that at least one ball is red?
(a) 55 (b) 50

(c) 10 (d) 5 NIPER JEE 2023 Question Paper

Correct Answer : (a) 55

134. Which type of statistics is used to make conclusions about the population using
analytical tools?
(a) Descriptive statistics (b) Inferential statistics
(c) Assumption testing (d) Simple statistics
Correct Answer : (b) Inferential statistics

135. Kinase enzymes family is:
(a) Oxidoreductases (b) Transferases
(c) Hydrolases (d) Translocases
Correct Answer : (b) Transferases

136. All of the following statements about Propofol are true except:
(a) It causes neurodegeneration in developing neurons
(b) It causes pain on intravenous administration
(c) It produces dissociative anesthesia
(d) It is the induction agent of choice in day care anesthesia.
Correct Answer : (c) It produces dissociative anesthesia

137. Which one of the following muscle relaxants has the maximum duration of
action?
(a) Rocuronium (b) Doxacurium
(c) Atracurium (d) Vecuronium
Correct Answer : (b) Doxacurium

138. Which of the following is autosomal recessive genetic disease that affects cell
membrane of RBCs?
(a) Cystic fibrosis (b) Sickle cell anemia
(c) Tay-Sachs disease (d) Hereditary elliptocytosis

m
m
c. o Correct Answer : (b) Sickle cell anemia .co
s em
em la

s a g
139. Isoniazid with ethambutol together exacerbates the adverse effects as:
(a) Hepatotoxicity (b) Neurotoxicity
(c) Renal toxicity (d) Ototoxicity
Correct Answer : (b) Neurotoxicity

m
c o m
140. Which is the currently used way to attenuate virus in vaccine preparation?
m .co
(a) Serial passage of .the virus in a heterologous host animal or cultured cells e
em las
l
(b) Selection ofascold-adapted mutants
ag
a g
(c) Gene deletion or site-directed mutagenesis
(d) Formic acid or heat treatment
Correct Answer : (a) Serial passage of the virus in a heterologous host animal or
cultured cells

m
.co
141. Which of the statement about hypericin is not correct?
(a) It is a naphthodianthrone derivative.
e m
(b) Its antidepressant activity is due to a
l s
the inhibition of re-uptake of certain
neurotransmitters ag
(c) It causes photosensitivity
(d) It is derived from shikimate pathway
Correct Answer : (d) It is derived from shikimate pathway

m
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142. All of the following are excitatory amino acids except:
m
.co m
(a) Aspartate (b) Glutamate
s e
s em(c) Glycine (d) GABA
g l a
g la Correct Answer : (d) GABA a
a
143. DrugBank is what type of source?
(a) Primary (b) Secondary
(c) Tertiary (d) None of the above

Correct Answer : (c) Tertiary NIPER JEE 2023 Question Paper

144. All of the following are bidentate ligands except:
(a) Ethylene diamine
(b) Oxalate ion
(c) Phenanthroline
(d) Dietylenetriamine
Correct Answer : (d) Dietylenetriamine

145. Conversion of alkyne to alkene is done by:
(a) LiAlBH44
(b) Lindlar catalyst
(c) Birch reduction
(d) NaBH44
Correct Answer : (b) Lindlar catalyst

146. What is the order of acidity of benzoic acid p-nitrobenzoic acid p-tolyl benzoic
acid, p-methoxy benzoic acid. https://www.pyqonline.com
(a) p-nitrobenzoicacid>benzoicacid> p-tolyl benzoic acid >p-methoxybenzoicacid
(b) p-nitro benzoic acid > benzoic acid > p-methoxy benzoic acid> p-tolyl benzoic acid
(c) p-tolyl benzoic acid > benzoic acid > p-methoxy benzoic acid > p-nitro benzoic acid
(d) benzoic acid > p-methoxy benzoic acid > p-tolyl benzoic acid > p-nitro benzoic acid
Correct Answer : (a) p-nitrobenzoicacid>benzoicacid> p-tolyl benzoic acid >p-
methoxybenzoicacid

147. Compounds in food that foster growth or activity of beneficial microorganisms
are:
(a) Probiotics (b) Prebiotics
(c) Conbiotics (d) Symbiotics
Correct Answer : (b) Prebiotics

m
m
c. o 148. The nucleophilic substitution reactions in pyridine occursemainly .co
m at the:
m (a) 2-position (b) 3-position la

se ag
(c) 4-position (d) 2 and 3-position
Correct Answer : (a) 2-position

149. HNO33 + Con H22SO44 (nitrating mixture) reacts with benzene to give
nitrobenzene at 323°K and m-dinitrobenzene at 373°K Which ion is formed by
m
.co
reaction of H22SO44 and HNO33?
m
(a) Nitronium ion
.co (b) Nitrate ion
s e m
s em
(c) Nitrosonium ion (d) Nitride ion
g la
g la : (a) Nitronium ion a
a
Correct Answer

150. The Ayurvedic dosage forms formed with calcination are;
(a) Lehya (b) Asava
(c) Bhasma (d) Churna

m
Correct Answer : (c) Bhasma

.co
s em
la
151. The presence of which element is indicated by a peak at m/z 127 and a
g
a (b) Br
characteristic 127 unit gap in the mass spectrum?
(a) I
(c) Cl (d) F
Correct Answer : (a) I

152. Cyclic amides are called:
m
o m
(a) lactones
c
(b) lactams
m .co
m . aminals s e
s e
(c) (d) imines
g l a
l a Correct Answer : (b) lactams a
ag
153. Hydrophilic polymers for a swellable matrix do not include?
(a) Hydroxy propyl methyl cellulose (b) Sodium Alginate
(HPMC)

(c) Poly (ethylene oxide) (d) Cellulose acetate NIPER JEE 2023 Question Paper

Correct Answer : (d) Cellulose acetate

154. What will be number and nature of peaks in high resolution NMR for ethyl methyl
ether?
(a) Three peaks as singlet, triplet, (b) Two peaks as each as singlet
quartet
(c) Two peaks each as triplet (d) Three peaks as doublet, triplet and
quarte
Correct Answer : (a) Three peaks as singlet, triplet, quartet

155. Absorption of what type of electromagnetic radiation results in ionization?
(a) X-rays (b) Radio waves
(c) Microwaves (d) Ultraviolet light
Correct Answer : (a) X-rays

156. Which compound would be expected to show intense IR absorption at 2820,
2710 and 1705 cm-1?
(a) CH3COCH2CH3
(b) PhCOCH3
(c) PhCHO
(d) CH2=CHCOCl
Correct Answer : (c) PhCHO

157. Which compound would be expected to show intense IR absorption at 3363,
3185, 1660 cm-1?
(a) CH3CH2CH2OH
(b) (CH3)2CHNH2
(c) CH3CH2CONH2
(d) But-1-ene
Correct Answer : (c) CH3CH2CONH2

m
m
c. o 158. The Central Government may constitute an advisory committee .co
m to be called to
s e
m advise the Central Government, the State Governments andlaothers on any matter

se tending to secure uniformity throughout India. It is: ag
(a) Drugs Technical Advisory Board (b) Drugs Consultative Committee
(c) Pharmacy Council of India (d) Indian Drug Manufacturers'
Association
Correct Answer : (b) Drugs Consultative Committee

m
m .co
.co m
159. D & C Act 1940 Rules 1945, which section gives the powers to the drug inspector

m
to collect sample of drugs/cosmetics preparation?
s e
as e g la
(a) 20
l (b) 21
a
(c) 22 ag (d) 23
Correct Answer : (c) 22

160. Which of the following statements is/are true?
P. Two equivalents of Grignard reagent react with acid chlorides to yield tertiary

m
alcohols after hydrolysis.

.co
Q. LiAlH4 reacts with acid chlorides to yield secondary alcohols after hydrolysis.
m
e
R. LiAlH[OC(CH3)3]3 reacts with acid chlorides to yield primary alcohols after
s
hydrolysis.
g la
a
S. LiAlH4 reduces carboxylic acids, acid chlorides, and esters to primary alcohols.
(a) P and Q (b) Q and R
(c) Q and S (d) P and S
Correct Answer : (d) P and S

m
.co
161. What is the characteristic of drug degrading by a second order reaction?
m
.co m
(a) Rate of degradation is independent on the concentration
s e
s em(b) Decline in drug concentration is linear g l a
g la (c) The t and T decrease with an increase in initial concentration
a
a
1/2 90%

(d) Most pharmaceutical products are found to get degrade by this order
Correct Answer : (c) The t1/2 and T90% decrease with an increase in initial
concentration

162. The maximum denticity of the polydentate ligand tetraethylenepentamine is:

(a) 5 (b) 4 NIPER JEE 2023 Question Paper

(c) 3 (d) 2
Correct Answer : (a) 5

163. Which one of the following is required for the development of B-cells in the bone
marrow?
(a) Stromal cells (b) Dendritic cells
(c) Kupffer cells (d) NK cells
Correct Answer : (a) Stromal cells

164. Rhubarb is used as:
(a) Laxative (b) Antacid
(c) Antirheumatic (d) Anthementic
Correct Answer : (a) Laxative

165. What is paraphrasing?
(a) Copying a passage word for word (b) Changing a few words in a passage
(c) Rewriting a passage in your own (d) Summarizing a passage
words
Correct Answer : (c) Rewriting a passage in your own words

166. Which graph is used to compare two known variables?
(a) Bar chart (b) Scatter plot
(c) Box plot (d) Bubble chart
Correct Answer : (b) Scatter plot

167. Which of the software is used for plagiarism check?
(a) Turnitin (b) Grammerly
(c) Fast pencil (d) Mendeley
Correct Answer : (a) Turnitin

m
m
c. o 168. Which one is not a correct pair of Institute and Place? sem .co
m (a) Pasteur Institute of India, Coonoor (b) Enterovirus Researchla

se Mumbai ag Centre, Parel,

(c) National Institute of Biologicals, (d) Centre of Advanced Research in
NOIDA Virology, Christian Medical College, Chennai
Correct Answer : (d) Centre of Advanced Research in Virology, Christian Medical
College, Chennai

m
m .co
.co m
169. Which is the world's first approved DNA plasmid vaccine:
s e
(a) HepB
s em (b) Covishield
g la
(c) ZyCoV-D la a
ag : (c) ZyCoV-D
(d) Covaxin
Correct Answer

170. Which is not a starch based excipient?
(a) Lycatab® (b) Uni-Pure®
(c) PharmGel (d) Emdex
m
Correct Answer : (d) Emdex
.co
s em
la second order reaction?
171. What is the unit of rate constantgfor
(a) min -1
a
(b) M-1 min-1
(c) M. L-1. min-1
(d) M-1
Correct Answer : (b) M-1 min-1
m
c o m m .co
. s e
em(a) Should be resistant to acidic pH of stomach a
172. All of the following are required characteristics of prebiotic except:
s g l
la a
ag (b) Should not be hydrolyzed by mammalian enzymes
(c) Should not be absorbed in the gastrointestinal tract
(d) Should not be fermented by intestinal microbiota
Correct Answer : (d) Should not be fermented by intestinal microbiota

173. The SI unit of radioactivity is:
(a) Becquerel (Bq) (b) Curie (Ci)
(c) Rad (d) Siemens (S)
Correct Answer : (a) Becquerel (Bq)

174. Boerhavia diffusa is a species of flowering plant commonly known as
(a) Punarnava (b) Shatavari
(c) Ativishaa or Amruta (d) Zendu
Correct Answer : (a) Punarnava

175.

Correct Answer : (a)

176. In the X-ray crystallography of protein, the scattering pattern of x-rays from the
protein crystal is primarily due to:
(a) Aminoacids (b) Carbon atoms
(c) Electrons (d) Protons
Correct Answer : (c) Electrons

177. Guaifenesin is:
(a) Mucokinetic expectorant (b) Mucolytic expectorant

m
m
c. o (c) Antitussive m.co
(d) Demulcent
s e
em a

s Correct Answer : (a) Mucokinetic expectorant
g l
a
178. The pathway of a tRNA during polypeptide elongation on the ribosome is:
(a) A site → P site → E site (b) P site Entry site → Exit site
(c) A site → P site → Entry site (d) P site → A site → E site
Correct Answer : (a) A site → P site → E site
m
c o m m .co
179. Therapeutic use. of Acetyl choline is NOT possible because it is: e
embound las
l as
(a) Highly protein (b) Rapidly degraded
ag
agexcreted
(c) Rapidly (d) None of the above
Correct Answer : (b) Rapidly degraded

180. Select the option with the correct spelling:
(a) Disappointment (b) Dissappointment
m
.co
(c) Desapointment (d) Disapointmint
Correct Answer : (a) Disappointment
s em
g la
181. Individuals were studied for aacontinuous period of 10 years in a research
project. The statement is an example of:
(a) Cross-sectional study
(b) Semi-longitudinal study
(c) Cohort study
m
.co
(d) Longitudinal study
m
.co
Correct Answer : (d) Longitudinal study
s e m
s em g l a
g la 182. Using Fick's law of diffusion how will flux change if membrane
a thickness is
a doubled?
(a) It will double. (b) It will quadruple.
(c) It will halve. (d) It will not change.
Correct Answer : (c) It will halve.

183. Which is not a scientific site?
(a) Research Gate (b) Scopus
(c) Web of Science (d) Google Plus
Correct Answer : (d) Google Plus

184. Which state has the Health Index progressive report in current year?
(a) Rajasthan (b) Kerala
(c) Manipur (d) Tamil Nadu
Correct Answer : (b) Kerala

185. World Cancer Day (WCD) is observed every year on:
(a) 4 February (b) 4 December
(c) 17 February (d) 31 March
Correct Answer : (a) 4 February

186. The first person, who did the mechanical separation of the racemic mixture into
individual enantiomer is:
(a) Friedrich Wöhler (b) Jacobus Henricus van't Hoff
(c) Emily Fischer (d) Louis Pasteur
Correct Answer : (d) Louis Pasteur

187. Treatment of a nitrile with a Grignard reagent followed by hydrolysis results in
__________.
(a) an ester (b) a ketone
(c) an ether (d) an alcohol
Correct Answer : (b) a ketone

188. Benzene can be considered as:
(a) [6]annulene (b) (4)annulene
(c) [2]annulene (d) None of the above

m
m
c. o Correct Answer : (a) [6]annulene m.co
s e
em a

s g l
a
189. The diffusion current in a polarogram is proportional to:
(a) Residual current (b) Migration current
(c) Wave height (d) Concentration of supporting
electrolyte
Correct Answer : (c) Wave height
m
m .co
.co
190. Golden rice is created by transforming genes related to:
s e m
s em g la
la
(a) Hormone synthesis (b) Beta-carotene synthesis
(c) Proteingsynthesis
a
a (d) Carbohydrate synthesis
Correct Answer : (b) Beta-carotene synthesis

191. New-Delhi-beta-Lactamase-1 was first time detected in:
(a) Pseudomonas aeruginosa (b) Acinetobacter baumanii

m
.co
(c) Staphylococcus aerus (d) Klebsiella pneumonia

em
Correct Answer : (d) Klebsiella pneumonia

las
g
192. Creatinine clearance is used asaa measurement of:
(a) Renal excretion rate (b) Glomerular filtration rate
(c) Active renal secretion (d) Passive renal absorption
Correct Answer : (b) Glomerular filtration rate

m
.co
193. Compartment modeling is explained by assuming:
m
.co
(a) Rate of drug release is first order
em
(b) Drug disposition is first order
s
s em(c) Rate of drug absorption is constant g la is zero
(d) Rate of drug elimination
g la order a
a Correct Answer : (b) Drug disposition is first order

194. Which of the following drug shows highest incidences of extrapyramidal adverse
effects?

(a) Quteipine (b) Haloperidol NIPER JEE 2023 Question Paper

(c) Risperidone (d) Olanzapine
Correct Answer : (b) Haloperidol

195. Which is false about melatonin?
(a) 5-Methoxy-N-acetyltryptamine
(b) Antioxidant and free radical scavenger
(c) Released from pineal gland
(d) Responsible for feeling alert and awake
Correct Answer : (d) Responsible for feeling alert and awake

196. What is the meaning of Mohenjodaro?
(a) Mound of the dead men (b) City of wells
(c) Mound of bricks, beads and bones (d) Mound of creation
Correct Answer : (a) Mound of the dead men

197. To describe the pharmacokinetics of intravenous anesthetic which compartment
model is used?
(a) One (b) Two
(c) Three (d) Any of the above depending on the
agent
Correct Answer : (c) Three

198. Enzymes involved in degradation of H22O22 are catalase and _________.
(a) Glutathione peroxidase (b) Glutathione reductase
(c) 5-Alpha reductase (d) Superoxide dismutase
Correct Answer : (a) Glutathione peroxidase

199. The major metabolite of Chloramphenicol is:
(a) O-Glucoronate of chloramphenicol (b) Reduction of Nitro group and its
acetylation

m
m
c. o (c) N-Glucoronate of chloramphenicol m .co
m s e
(d) Aromatic hydroxylation and its
a

se l
gluconronate
Correct Answer : (a) O-Glucoronate of chloramphenicola
g

200. The drug of choice for tapeworm infection is:
(a) Praziquantel (b) Prazocin
(c) Pramlintide (d) Castor oil
m
m .co
Correct Answer : (a) Praziquantel

m .co s e m
as e g la
l a
ag

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m .co
s e
g la
a

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s e g l a
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a