NIPER JEE 2025 Question Paper

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NIPER JEE 2025
Question Paper
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NIPER JEE 2025 Question Paper

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Disclaimer: ag
This question paper is based on memory and may not be 100% accurate. The answers provided are
tentative and prepared for practice purposes only. There may be errors or differences from the
actual exam. Users are advised to verify answers from official sources.

1. Which group will show a red shift (bathochromic shift)?
(a) NHCOCH33
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(b) C=O
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(c) Cl
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(d) All of the above
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Answer : (d) All of the above

2. FSSAI works under which ministry?
(a) Ministry of Agriculture
(b) Ministry of Health and Family Welfare
(c) Ministry of Consumer Affairs
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(d) Ministry of Food Processing Industries

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Correct Answer : (b) Ministry of Health and Family Welfare
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a during short-term stress?
3. Which hormone is commonly released
(a) Insulin
(b) Adrenaline
(c) Glucagon
(d) Estrogen
Correct Answer : (b) Adrenaline
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4. Father of chemotherapy:
s em
s em (a) Paul Ehrlich
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(b) Hippocrates
(c) Galen
(d) Ramnath Chopra
Correct Answer : (a) Paul Ehrlich

5. Which amino acid does not occur naturally?

(a) Histidine
NIPER JEE 2025 Question Paper
(b) Phenylephrine
(c) Arginine
(d) Aspartic acid
Correct Answer : (b) Phenylephrine

6. Albinism is associated with which amino acid?
(a) Tyrosine
(b) Phenylalanine
(c) Tryptophan
(d) Histidine
Correct Answer : (a) Tyrosine

7. SERM full form in chemotherapy:
(a) Selective Estrogen Receptor Modulators
(b) Selective Estrogen Receptor Medication
(c) Systemic Estrogen Receptor Management
(d) Specific Estrogen Receptor Molecule
Correct Answer : (a) Selective Estrogen Receptor Modulators

8. Which of the following drugs exhibits zero-order kinetics at high or toxic doses?
(a) Paracetamol
(b) Aspirin
(c) Amoxicillin
(d) Metformin
Correct Answer : (b) Aspirin

9. Which of the following is produced by a biological system?
(a) Toxin
(b) Toxicant
(c) Poison
(d) Xenobiotics
Correct Answer : (a) Toxin

10. Which is the final electron acceptor in the electron transport chain?
(a) Oxygen

m
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(d) FAD ag
Correct Answer : (a) Oxygen

11. Which of the following is a DPP-4 inhibitor?
(a) Glibenclamide
(b) Sitagliptin
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(c) Metformin
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(d) Acarbose .co s e m
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Correct Answer : (b) Sitagliptin
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a technologies should ____ at least match new technology.
12. Modern
(a) With
(b) Of
(c) In
(d) Was
Correct Answer : (c) In
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13. Sedimentation is directly proportional to: e
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(a) Surface Area
(b) Viscosity
(c) Density
(d) Volume
Correct Answer : (c) Density

14. Quinine is obtained from which of the following? m
m Cinchona
c. o(b) Camptotheca
(a)
m .co
s e
s em g l a
l a (c) Ipecac a
ag (d) Opium
Correct Answer : (a) Cinchona

15. Choose the correct synonym of the word Exaggerate:
(a) Minimize
(b) Understate

(c) Amplify
NIPER JEE 2025 Question Paper
(d) Reduce
Correct Answer : (c) Amplify

16. The HLB (Hydrophilic-Lipophilic Balance) value of antifoaming agents is:
(a) 1-3
(b) 4-6
(c) 8-18
(d) Above 20
Correct Answer : (a) 1-3

17. "Orange peel effect" is shown during which phase?
(a) Blending
(b) Coating
(c) Polishing
(d) Drying
Correct Answer : (b) Coating

18. Pinacol-pinacolone rearrangement converts:
(a) 1,2-diol
(b) 1,1-diol
(c) 1,3-diol
(d) 1,4-diol
Correct Answer : (a) 1,2-diol

19. Alzheimer's disease is caused by:
(a) Beta amyloid accumulation
(b) Decreased dopamine
(c) Decreased acetylcholine
(d) Both A and C
Correct Answer : (d) Both A and C

20. Coating of Eudragit NE40D on tablets is done to prepare:
(a) Buccal tablets
(b) Sublingual tablets
(c) CR tablets

m
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se Correct Answer : (c) CR tablets
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21. BCS (Biopharmaceutics Classification System) Class II drugs are characterized by:
(a) High solubility, high permeability
(b) Low solubility, low permeability
(c) Low solubility, high permeability
(d) High solubility, low permeability
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Correct Answer : (c) Low solubility, high permeability
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(a) IgG la
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22. Which antibody is first produced against an antigen?
g la
a
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(b) IgA
(c) IgM
(d) IgE
Correct Answer : (c) IgM

23. Benzyl alcohol as a preservative is not typically used in injections for which group?
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(a) Adults
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(b) Children
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(c) Elderly
(d) Pregnant women
Correct Answer : (b) Children

24. As per I.P., if the solubility range of a solute is 1 to 10 parts, it is classified as:
(a) Soluble
(b) Freely soluble m
m Sparingly soluble
c. o(d) Slightly soluble
(c)
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s em g l a
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26. Montelukast acts on which of the following receptors to block the action of leukotrienes LTC44 and
LTD44?
(a) CysLT11 receptor
(b) H22 receptor
(c) CB22 receptor

(d) Muscarinic receptor
NIPER JEE 2025 Question Paper
Correct Answer : (a) CysLT11 receptor

27. Combustion of natural gas is which type of reaction?
(a) Exothermic
(b) Endothermic
(c) Displacement
(d) Neutralization
Correct Answer : (a) Exothermic

28. In which drug therapy is body surface area (BSA)-based dose adjustment required?
(a) Chemotherapy
(b) Antibiotics
(c) Antipyretics
(d) Anti-inflammatories
Correct Answer : (a) Chemotherapy

30. Which is not a detector in Gas Chromatography?
(a) FID
(b) ECD
(c) TCD
(d) Array diode detector
Correct Answer : (d) Array diode detector

31. Choose the correct spelling:
(a) Ocassion
(b) Occasion
(c) Occassion
(d) Ocacsion
Correct Answer : (b) Occasion

32. According to the n+1 rule, 3,3-dibromoethane will show which type of splitting in NMR?
(a) Singlet
(b) Doublet
(c) Triplet
(d) Quartet

m
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33. Which of the following drugs is commonly used to treat MRSAginfections?
a
(a) Amoxicillin
(b) Vancomycin
(c) Ceftriaxone
(d) Metronidazole
Correct Answer : (b) Vancomycin
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34. Which of the following drugs is classified as an ACE inhibitor?
s e
(a) Losartan
s em g la
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(b) Enalapril a
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(c) Spironolactone
(d) Amlodipine
Correct Answer : (b) Enalapril

35. Which of the following drugs acts on the Renin-Angiotensin-Aldosterone System (RAAS)?
(a) Atenolol
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(b) Furosemide
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(c) Enalapril
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(d) Digoxin
Correct Answer : (c) Enalapril

36. Choose the correct synonym of the word August:
(a) Ordinary
(b) Humble
(c) Majestic m
c o m Common
(d)
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s e Correct Answer : (c) Majestic
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ag 37. G20 Summit 2024 was held in:
(a) USA
(b) India
(c) Brazil
(d) China
Correct Answer : (c) Brazil

38. Protein responsible for maintaining osmotic (oncotic) pressure in the body is:NIPER JEE 2025 Question Paper
(a) Heparin
(b) Albumin
(c) Globulin
(d) Fibrinogen
Correct Answer : (b) Albumin

39. Myokines are:
(a) Proteins released by muscle cells
(b) They drink alcohol
(c) Men who oppress women
(d) People who avoid social gatherings
Correct Answer : (a) Proteins released by muscle cells

40. Most abundant protein in the human body is:
(a) Collagen
(b) Hemoglobin
(c) Albumin
(d) Keratin
Correct Answer : (a) Collagen

41. Atropine mechanism of action:
(a) Muscarinic antagonist
(b) Neuromuscular agonist
(c) Neuromuscular antagonist
(d) Ganglionic blocker
Correct Answer : (a) Muscarinic antagonist

42. The study of Earth is called:
(a) Geology
(b) Ecology
(c) Astrology
(d) Meteorology
Correct Answer : (a) Geology

m
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se (a) sec-1-1
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(b) Mole litre sec ag
(c) Mole sec-1-1
(d) Mole-1-1
Correct Answer : (a) sec-1-1

44. Rancidity of oil is detected by:
m
(a) Iodine value
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(b) Saponification value
s e m
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(c) Peroxide value
g a
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(d) Acetyl
Correct Answer : (c) Peroxide value

45. Find the angle at 5:00 PM.
(a) 30°
(b) 60°
(c) 150°
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(d) 90°
Correct Answer : (c) 150°
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46. Which of the following gives a positive Tollen's test?
(a) Ethanal
(b) Methanal
(c) Ethanol
(d) Glucose
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Correct Answer : (b) Methanal
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m . The relative sweetness of saccharin compared to sucrose is approximately:sem
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s e (a) 200 times
47.
g l a
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(c) 500 times
(d) 1000 times
Correct Answer : (c) 500 times

48. Which is the method to determine enantiomeric excess (ee)?

(a) UV spectroscopy
NIPER JEE 2025 Question Paper
(b) IR spectroscopy
(c) NMR spectroscopy
(d) Polarimetry
Correct Answer : (d) Polarimetry

49. Which of the following does not describe Microcrystalline Cellulose (MCC)?
(a) Non-fibrous
(b) Slightly soluble in water
(c) Used as disintegrant
(d) Insoluble in water
Correct Answer : (b) Slightly soluble in water

50. Longest acting insulin:
(a) Glargine
(b) Lispro
(c) Detemir
(d) Aspart
Correct Answer : (a) Glargine

51. Which drug is obtained from a marine source?
(a) Agar-agar
(b) Cassia angustifolia
(c) Cantharide
(d) Asbestos
Correct Answer : (a) Agar-agar

53. Talc is used as:
(a) Binder
(b) Diluent
(c) Disintegrant
(d) Preservative
Correct Answer : (b) Diluent

54. Caffeine and theophylline cause CNS stimulation by:
(a) Adenosine receptor antagonist

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(d) Acetylcholinesterase ag
Correct Answer : (a) Adenosine receptor antagonist

55. Maillard reaction occurs between:
(a) Amine and lactose
(b) Protein and sugar
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(c) Amino acid and glucose
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(d) Protein and enzyme .co s e m
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Correct Answer : (c) Amino acid and glucose
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a metal is present in Vitamin B 12?
56. Which 12

(a) Iron
(b) Magnesium
(c) Cobalt
(d) Zinc
Correct Answer : (c) Cobalt
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57. Which of the following is a biological product?

g l a
a
(a) Betamethasone
(b) Retinoic acid
(c) Cyanocobalamin
(d) Paracetamol
Correct Answer : (c) Cyanocobalamin

58. Aldol condensation reactivity order for: m
m .co
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I. Benzaldehyde
II. p-Methoxybenzaldehyde
em
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III. p-Nitrobenzaldehyde
l as
l as IV. Formaldehyde
ag
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(a) I > II > III > IV
(b) I > III > II > IV
(c) IV > III > I > II
(d) IV > I > II > III
Correct Answer : (c) IV > III > I > II

59. Levodopa : Carbidopa :: Imipenem : ?
NIPER JEE 2025 Question Paper
(a) Metronidazole
(b) Clavulanic acid
(c) Cilastatin
(d) Sulbactam
Correct Answer : (c) Cilastatin

60. Contact lenses are typically made from:
(a) Polystyrene
(b) Polyvinyl chloride (PVC)
(c) Silicone hydrogel
(d) Polymethyl methacrylate (PMMA)
Correct Answer : (c) Silicone hydrogel

61. For which of the following alkaloids is Mayer's test negative but Murexide test positive?
(a) Indole alkaloid
(b) Isoquinoline alkaloid
(c) Purine alkaloid
(d) Tropane alkaloid
Correct Answer : (c) Purine alkaloid

62. Tablets adhesion to the die wall during tablet compression is called:
(a) Picking
(b) Sticking
(c) Capping
(d) Lamination
Correct Answer : (b) Sticking

63. Sodium Cromoglycate is used as:
(a) Bronchodilator
(b) Mast cell stabilizer
(c) Antihistamine
(d) Corticosteroid
Correct Answer : (b) Mast cell stabilizer

64. Which of the following is a sex-linked disorder?

m
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(c) Cystic fibrosis ag
(d) Thalassemia
Correct Answer : (b) Hemophilia

65. Which neurotransmitter is formed by glutamate decarboxylation?
(a) Dopamine
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(b) GABA
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(c) Glutamine .co s e m
s em g la
la : (b) GABA
(d) Glycine
g a
a
Correct Answer

66. The solubility enhancement of caffeine by sodium benzoate is an example of:
(a) Hydrotropy
(b) Complexation
(c) Co-solvency
(d) Solubilization
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Correct Answer : (a) Hydrotropy
s
la the order of basicity?
a g
67. Which of the following correctly represents
(a) Pyridine > Imidazole > Pyrrole
(b) Imidazole > Pyridine > Pyrrole
(c) Pyrrole > Pyridine > Imidazole
(d) Imidazole > Pyrrole > Pyridine
Correct Answer : (b) Imidazole > Pyridine > Pyrrole
m
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c. o(a) 2,2-Dibromo-1-butyne
68. IUPAC name of Br22C=C=C-CH33:
m .co
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s em g l a
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ag (c) 1,2-Dibromo-3-butene
(d) 3,3-Dibromo-1-butene
Correct Answer : (a) 2,2-Dibromo-1-butyne

69. Hormone released from the zona glomerulosa:
(a) Aldosterone https://www.pyqonline.com

(b) Mineralocorticoid
NIPER JEE 2025 Question Paper
(c) Adrenaline
(d) Dopamine
Correct Answer : (a) Aldosterone

70. Orthopedic transplants are primarily made of which of the following materials?
(a) Silicone
(b) Titanium alloy
(c) Polystyrene
(d) Teflon
Correct Answer : (b) Titanium alloy

71. Heart valve transplants are commonly made of which of the following materials?
(a) Silicone rubber
(b) Stainless steel
(c) Carbon
(d) Polyethylene glycol
Correct Answer : (c) Carbon

72. Bevacizumab is a type of inhibitor.
(a) Tyrosine kinase inhibitor
(b) VEGF inhibitor
(c) Protease inhibitor
(d) COX inhibitor
Correct Answer : (b) VEGF inhibitor

73. Which among the following doesn't contain anethole?
(a) Fennel
(b) Anise
(c) Holy Basil
(d) All of the above
Correct Answer : (c) Holy Basil

74. Least number to be subtracted from 9999 so that it is completely divisible by 19:
(a) 5
(b) 6

m
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se (d) 3
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Correct Answer : (c) 4 ag
75. Symptoms of muscarinic poisoning include:
(a) Tachycardia
(b) Hypotension
(c) Dry mouth
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(d) Constipation
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Correct Answer : (b) Hypotension
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76. Asthma isla a
g treated with:
(a) β1aagonist
(b) β2 agonist
(c) α agonist
(d) Muscarinic antagonist
Correct Answer : (b) β2 agonist

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77. Which of the following is not obtained from animals?
m
(a) Heparin
s e
g l a
a
(b) Captopril
(c) Erythromycin
(d) Premarin
Correct Answer : (b) Captopril

78. Fick’s law is used for the study of:
(a) Dissolution rate m
m Disintegration rate
c. o(c) Dissociation rate
(b)
m .co
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s em g l a
l a (d) Passive diffusion a
ag Correct Answer : (d) Passive diffusion

79. Bloom strength is a measure of the strength of which polymer?
(a) Gelatin
(b) Starch
(c) Cellulose

(d) Polyvinylpyrrolidone (PVP)
NIPER JEE 2025 Question Paper
Correct Answer : (a) Gelatin

80. Which of the following forms a white precipitate of silver halide?
(a) NaCl
(b) NaOH
(c) Na22CO33
(d) CH33COONa
Correct Answer : (a) NaCl

81. Ethambutol acts via inhibiting:
(a) Protein synthesis
(b) Mycolic acid synthesis
(c) Cell wall synthesis
(d) DNA
Correct Answer : (c) Cell wall synthesis

82. Entacapone and Tolcapone are which type of enzyme inhibitors?
(a) MAO-B inhibitors
(b) COMT inhibitors
(c) Acetylcholinesterase inhibitors
(d) DOPA decarboxylase inhibitors
Correct Answer : (b) COMT inhibitors

83. Myxedema coma is a severe complication of which condition?
(a) Hyperthyroidism
(b) Hypothyroidism
(c) Cushing's syndrome
(d) Addison's disease
Correct Answer : (b) Hypothyroidism

84. A higher Hausner ratio indicates:
(a) Excellent flow
(b) Good flow
(c) Passable flow
(d) Poor flow

m
m
c. o Correct Answer : (d) Poor flow m .co
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85. mTOR inhibitor is:
ag
(a) Sirolimus
(b) Cycloserine
(c) Tacrolimus
(d) Anakinra
Correct Answer : (a) Sirolimus
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86. What is the isoelectric point if pKa1 = 2.18 and pKa2 = 8.85?
m s e
(a) 0.92
(b) 4 la
s e g la
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(c) 9.87
(d) 5.5
Correct Answer : (d) 5.5

87. Protein responsible for osmolarity balance in the body:
(a) Heparin
o m
(b) Albumin
m .c
(c) Globulin
s e
g l a
a
(d) Collagen
Correct Answer : (b) Albumin

88. Philistine refers to someone who:
(a) They wear full dress and all
(b) They drink alcohol
(c) They lack cultural refinement m
c o m They avoid social gatherings
(d)
m .co
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g l a
l a a
ag 89. Drug of choice (DOC) for cerebral malaria:
(a) Artemisinin
(b) Chloroquine intravenous
(c) Primaquine
(d) Quinine oral
Correct Answer : (a) Artemisinin

NIPER JEE 2025 Question Paper
90. Where does primary absorption of drugs occur?
(a) Stomach
(b) Small intestine
(c) Large intestine
(d) Liver
Correct Answer : (b) Small intestine

91. Sublimation in lyophilisation occurs at which stage?
(a) Pre-treatment
(b) Primary drying
(c) Secondary drying
(d) Freezing
Correct Answer : (b) Primary drying

92. Replace the bold phrase: The man to who I sold my house was a cheat.
(a) to whom I sell
(b) to who I sell
(c) who was sold to
(d) to whom I sold
Correct Answer : (d) to whom I sold

93. First antimalarial drug:
(a) Chloroquine
(b) Quinine
(c) Artemisinin
(d) Amodiaquine
Correct Answer : (b) Quinine

94. Schedule O relates to:
(a) Standards for cosmetics
(b) Standards for disinfectants
(c) Standards for ophthalmic preparations
(d) Standards for parenteral preparations
Correct Answer : (b) Standards for disinfectants

m
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m s e NIPER JEE 2025 Question Paper

se (a) Paracetamol
l a
(b) Isoniazid ag
(c) Aspirin
(d) Ibuprofen
Correct Answer : (b) Isoniazid

96. What is the primary cause of Myasthenia Gravis?
m
m
(a) Genetic mutation in muscle cells
.co
.co
(b) Bacterial infection of the nervous system
s e m
s em g la
la of dopamine in the brain
(c) Autoimmune destruction of acetylcholine receptors
g a
a
(d) Deficiency
Correct Answer : (c) Autoimmune destruction of acetylcholine receptors

97. Which is a prodrug and is converted to nitric oxide?
(a) Nitroglycerin https://www.pyqonline.com
(b) Amyl nitrite
(c) Pentaerythritol
o m
(d) All of the above
m.c
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Correct Answer : (d) All of the above
g l a
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98. Which receptor acts by phosphorylation?
(a) GPCR
(b) Tyrosine Kinase
(c) Nuclear
(d) Ion Channel
m
.co
Correct Answer : (b) Tyrosine Kinase
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m
c emthan those in any other
. Choose the correct alternative: All over Russia, Indian films are more popular
s
s e country.
99.
g l a
la a
ag (a) in
(b) that in
(c) that of
(d) those of
Correct Answer : (d) those of

100. Which of the following compounds is most basic?
NIPER JEE 2025 Question Paper
(a) Acetic acid
(b) Phenol
(c) p-Nitrophenol
(d) o-Nitrophenol
Correct Answer : (b) Phenol

101. Which metal is present in Vitamin B1212?
(a) Manganese
(b) Ferric (Fe)
(c) Cobalt
(d) Copper
Correct Answer : (c) Cobalt

102. Find the word with the incorrect spelling:
(a) Penance
(b) Menace
(c) Tendancy
(d) Governance
Correct Answer : (c) Tendancy

103. Syphilis is caused by which microorganism?
(a) Entamoeba histolytica
(b) Plasmodium falciparum
(c) Treponema pallidum
(d) Brucella spp.
Correct Answer : (c) Treponema pallidum

105. Choose the correct spelling:
(a) Surveilance
(b) Survillance
(c) Surveillance
(d) Surveillence
Correct Answer : (c) Surveillance

106. Digoxin poisoning is treated with:

m
m (a) Magnesium sulfate .co
m .co s e m NIPER JEE 2025 Question Paper

se (b) Protamine sulfate
l a
(c) Flumazenil ag
(d) Digoxin immune Fab
Correct Answer : (d) Digoxin immune Fab

107. Find the odd one out:
(a) Retina
m
(b) Pupil
m .co
(c) Vision .co s em
s em g la
la : (c) Vision
(d) Cornea
g a
a
Correct Answer

108. Calculate the angle of repose (θ) if the height (h) is 3.3 cm and the diameter (d) is 9 cm.
(a) 36.25°
(b) 36.15°
(c) 26.25°
(d) 26.15°
o m
.c
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Correct Answer : (a) 36.25°
s
la to:
109. Wetting reaction in dental materialsgrefers
(a) Chemical setting of materials
a
(b) The ability of a liquid to spread over a surface
(c) Hardening of composite resins
(d) Thermal expansion of materials
Correct Answer : (b) The ability of a liquid to spread over a surface

o m
110.mWhat is the current term used in medical literature for Mental Retardation? .c
. co(a) Mental deficiency s em
m
e (b) Cognitive delay l a
las a g
ag (c) Intellectual disability
(d) Mental impairment
Correct Answer : (c) Intellectual disability

111. The 4f orbital belongs to which block in the periodic table?
(a) s-block

(b) p-block
NIPER JEE 2025 Question Paper
(c) d-block
(d) f-block
Correct Answer : (d) f-block

112. Beer-Lambert law is used in:
(a) UV-Visible spectroscopy
(b) IR spectroscopy
(c) NMR spectroscopy
(d) Mass spectroscopy
Correct Answer : (a) UV-Visible spectroscopy

113. What comes next in the series: 2, 6, 18, 54, ?
(a) 30
(b) 60
(c) 162
(d) 190
Correct Answer : (c) 162

114. What is Megaloblastic Anemia?
(a) Caused by iron deficiency
(b) Caused by the destruction of red blood cells
(c) Caused by a deficiency of vitamin B1212
(d) Due to chronic blood loss
Correct Answer : (c) Caused by a deficiency of vitamin B1212

115. Wolff-Kishner reaction is used for:
(a) Oxidation of alcohols to ketone
(b) Reduction of alkenes to alkane
(c) Conversion of aldehydes and ketones to alkanes
(d) Halogenation of aromatic compounds
Correct Answer : (c) Conversion of aldehydes and ketones to alkanes

116. The first drug launched under the 'Kalakar' health initiative is:
(a) Kalawantine
(b) Paracetamol

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Correct Answer : (a) Kalawantine ag
117. Which of the following is a common symptom of PCOD?
(a) Heavy menstrual bleeding
(b) Pain during ovulation
(c) Irregular menstrual cycle
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(d) Early menopause
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Correct Answer : (c) Irregular menstrual cycle
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118. Sodium-potassium pump follows which type of transport mechanism? a
a diffusion
(a) Simple
(b) Facilitated diffusion
(c) Primary active transport
(d) Secondary active transport
Correct Answer : (c) Primary active transport

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119. Which of the following does NOT give iodoform test?
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(a) Ethanol
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(b) Acetone
(c) Isopropanol
(d) Methanol
Correct Answer : (d) Methanol

120. What is the mechanism of action of Gleevec (Imatinib)?
(a) Monoclonal antibody against EGFR m
m DNA alkylating agent
c. o(c) Tyrosine kinase inhibitor targeting BCR-ABL
(b)
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121. A person who studies birds is called:
(a) Entomologist
(b) Ornithologist
(c) Herpetologist

(d) Ichthyologist
NIPER JEE 2025 Question Paper
Correct Answer : (b) Ornithologist