CBSE Class 12 Question Paper 2024 Biotechnology

CBSE

Series &RQPS SET-4
àíZ-nÌ H$moS>
Q.P. Code 99
amob Z§. narjmWu àíZ-nÌ H$moS> >H$mo CÎma-nwpñVH$m Ho$
Roll No. _wI-n¥ð >na Adí` {bIo§ &
Candidates must write the Q.P. Code
on the title page of the answer-book.

H¥$n`m Om±M H$a b| {H$ Bg àíZ-nÌ _o§ _w{ÐV n¥ð> 19 h¢ &
H¥$n`m Om±M H$a b| {H$ Bg àíZ-nÌ _| 33 àíZ h¢ &
àíZ-nÌ _| Xm{hZo hmW H$s Amoa {XE JE àíZ-nÌ H$moS> H$mo narjmWu CÎma-nwpñVH$m
Ho$ _wI-n¥ð> na {bI| &
H¥$n`m àíZ H$m CÎma {bIZm ewê$ H$aZo go nhbo, CÎma-nwpñVH$m _| àíZ H$m H«$_m§H$ Adí`
{bI| &
Bg àíZ-nÌ 15 {_ZQ >H$m g_` {X`m J`m h¡ & àíZ-nÌ H$m
10.15 ~Oo {H$`m OmEJm & 10.15 ~Oo go 10.30 ~Oo VH$ N>mÌ
Ho$db àíZ- -nwpñVH$m na H$moB© CÎma
Zht {bI|Jo &
Please check that this question paper contains 19 printed pages.
Please check that this question paper contains 33 questions.
Q.P. Code given on the right hand side of the question paper should be written
on the title page of the answer-book by the candidate.
Please write down the serial number of the question in the answer-book
before attempting it.
15 minute time has been allotted to read this question paper. The question
paper will be distributed at 10.15 a.m. From 10.15 a.m. to 10.30 a.m., the
students will read the question paper only and will not write any answer on the
answer-book during this period.
O¡d-àm¡Úmo{JH$s
BIOTECHNOLOGY
:3 : 70
Time allowed : 3 hours Maximum Marks : 70

1-99 Page 1 P.T.O.

:

:
(i) 33
(ii)
(iii) : 1 16 1

(iv) : 17 21
2
(v) : 22 28
3
(vi) : 29 30 4

(vii) : 31 33
5
(viii)

IÊS> H$ 16 1=16

1. Za AZwd©a nm¡Yo àmá H$aZo H$s ~mZ}µO E§µOmB_ VWm ~mañQ>ma àUmbr H$m àmH¥${VH$ òmoV h¡ : 1
(A)
(B)
(C)
(D)

2. \${eE§gr amoJ BgH$s AZwnpñW{V (A^md) Ho$ H$maU hmoVm h¡ : 1
(A) ES>rZmogrZ S>mB©\$m°ñ\o$Q>
(B) ES>rZmogrZ {S>E_rZoµO
(C)
(D) ½dmZrS>rZ ZmBQ´>oQ>

1-99 Page 2

General Instructions :
Read the following instructions carefully and follow them :
(i) This question paper contains 33 questions. All questions are compulsory.
(ii) Question paper is divided into five sections Section A, B, C, D and E.
(iii) Section A : Questions number 1 to 16 are Multiple Choice Type
Questions. Each question carries 1 mark.
(iv) Section B : Questions number 17 to 21 are Very Short Answer Type
Questions. Each question carries 2 marks.
(v) Section C : Questions number 22 to 28 are Short Answer (SA) Type
Questions. Each question carries 3 marks.
(vi) Section D : Questions number 29 and 30 are Case-based Questions
carrying 4 marks each. Each question has sub-parts with internal choice
in one sub-part.
(vii) In Section E : Questions number 31 to 33 are Long Answer (LA) Type
Questions. Each question carries 5 marks.
(viii) There is no overall choice given in the question paper. However, an
internal choice has been provided in few questions in all the Sections
except Section A.

SECTION A 16 1=16

1. The natural source of enzyme barnase and barstar, a system used to
achieve male sterile plant is : 1
(A) Bacillus subtilis
(B) Bartonella henselae
(C) Bacillus amyloliquefaciens
(D) Barnesville coli

2. Severe combined immunodeficiency disease is caused due to the absence
of : 1
(A) Adenosine diphosphate
(B) Adenosine deaminase
(C) Adenosine cyclase
(D) Guanidine nitrate
1-99 Page 3 P.T.O.

3. ________ joÌ _| hmoVm h¡ & 1
(A) H$moqS>J
(B) Zm°Z-H$moqS>J
(C) {Z`m_H$
(D)

4. H$m{`H$ ^«yUm| H$mo _________ AdñWm _| EH$ gwa{jV AmdaU _| g§nw{Q>V H$aHo$ H¥${Ì_ ~rOm|
H$m {Z_m©U {H$`m OmVm h¡ & 1
(A) Q>m°a{nS>mo
(B) ½bmoã`yba
(C) ~rOnÌ
(D) {Ì^wOmH$ma
5. nmÌo g§dY©Z _| O§Vw H$mo{eH$mAm| H$s ñdñW g§d¥{Õ H$mo àmoËgm{hV H$aZo hoVw noßQ>mBS> hm°_m}Z
VWm d¥{Õ H$maH$m| H$mo gm_mÝ`V: Bggo àmßV {H$`m OmVm h¡ & òmoV h¡ : 1
(A) \$sZm°b aoS>
(B) à{VO¡{dH$
(C) é{Ya gra_
(D) Eo_rZmo Aåb
6. Cg g§dmhH$ H$s nhMmZ H$s{OE Omo F-ßbm{µÁ ÎmmH$ma OrZmo_
dmbr H$mo{eH$mAm| H$mo g§H«${_V H$aVm h¡ : 1
(A)
(B) YEp
(C) pBR322
(D) M13

7. gyú_Ordr H$mo{eH$mAm| Ûmam CËnm{XV {ÛVr`H$ CnmnM`O H$m EH$ CXmhaU h¡ : 1
(A) {dQ>m{_Z
(B) EoëH$mohm°b
(C) Aåb
(D) à{VO¡{dH$
1-99 Page 4

3. Single nucleotide polymorphisms usually occur in __________ regions. 1
(A) Coding
(B) Non-coding
(C) Regulatory
(D) Exonic

4. Artificial seeds are produced by encapsulating the somatic embryos at the
___________ stage in a protective coating. 1
(A) Torpedo
(B) Globular
(C) Cotyledon
(D) Triangular

5. The peptide hormones and growth factors to promote healthy growth of
animal cells in vitro are often derived from : 1
(A) Phenol red
(B) Antibiotics
(C) Blood serum
(D) Amino acids

6. Identify the vector that infects E. coli cells containing F-plasmid and that
has a single-stranded circular genome : 1
(A) Agrobacterium tumefaciens
(B) YEp
(C) pBR322
(D) M13

7. An example of secondary metabolites produced by microbial cells
include : 1
(A) Vitamins
(B) Alcohol
(C) Acids
(D) Antibiotics
1-99 Page 5 P.T.O.

8. O~ EH$ AmZwd§{eH$Vm: ê$nm§V[aV µ\$gb go H$moB© {dOmVr` OrZ namJH$Umo§ Ho$ _mÜ`_ go
{H$gr g§~Y§ r nmXn àOm{V _| nbm`Z H$a OmVm h¡, Vmo Bgo H$hVo h¢ : 1
(A) OrZ ñWmZm§VaU
(B) OrZ àXÿfU
(C) S>rEZE g§XÿfU
(D) Am{dfmbwVm ñWmZm§VaU

9. 10,000 S>mëQ>Z AUw^ma VWm 5+ MmO© (Amdoe) dmbo àmoQ>rZ H$m g§h{V ñnoQ´>_{_{VH$
{díbofU {H$`m J`m & BgHo$ g§h{V-MmO© AZwnmV H$m A{^H$bZ H$s{OE & 1
(A) 2001 (B) 2000
(C) 2501 (D) 5001

10. ^«yU H$s H$moaH$nwQ>r (ãbmñQ>mo{gñQ>) AdñWm go àmßV H$s JB© ^«yUr` _yb H$mo{eH$mE± ______
àH¥${V H$s hmoVr h¢ & 1
(A) (B)
(C) ~hþj_ (_ëQ>rnmoQ>|Q>) (D)

11. à{VO¡{dH$ no{Z{g{bZ H$s CÀM gmÝÐVm Ho$ CËnmXZ _| g_W© H$m gwYarH¥$V ñQ´>oZ
h¡ : 1
(A)
(B)
(C)
(D)

12. ____________g§dYm] H$mo b§~o g_` VH$ ~ZmE aIZo Ho$ {bE CgH$m ~ma-~ma Cng§dY©Z
{H$`m OmVm h¡ & 1
(A) A§S>me` (B) àmoQ>moßbmñQ>
(C) H¡$bg $ (D) _mg gob

1-99 Page 6

8. When a transgene from a Genetically Modified crop escapes through
pollen to a related plant species, it is known as _______. 1
(A) Gene transfer
(B) Gene pollution
(C) DNA contamination
(D) Toxicity transfer

9. A protein ion with a molecular weight of 10,000 Daltons carried a charge
of 5+ and was subjected to mass spectrometric analysis. Calculate its
mass to charge ratio. 1
(A) 2001 (B) 2000
(C) 2501 (D) 5001

10. Embryonic stem cells derived from blastocyst stage of the embryo are
___________ in nature. 1
(A) Totipotent (B) Pluripotent
(C) Multipotent (D) Bipotent

11. An improved strain of Penicillium, capable of producing higher
concentration of antibiotic penicillin is : 1
(A) Penicillium notatum
(B) Penicillium chrysogenum
(C) Penicillium eutrophus
(D) Penicillium cerevisiae
12. ___________ cultures can be maintained for a prolonged period of time by
repeated sub-culturing. 1
(A) Ovary
(B) Protoplast
(C) Callus
(D) Mass cell

1-99 Page 7 P.T.O.

13 16 (A)
(R) (A), (B), (C)
(D)

(A) A{^H$WZ (A) Am¡a H$maU (R) XmoZm| ghr h¢ Am¡a H$maU (R), A{^H$WZ (A) H$s
ghr ì¶m»¶m H$aVm h¡ &
(B) A{^H$WZ (A) Am¡a H$maU (R) XmoZm| ghr h¢, naÝVw H$maU (R), A{^H$WZ (A) H$s
ghr ì¶m»¶m H$aVm h¡ &
(C) A{^H$WZ (A) ghr h¡, naÝVw H$maU (R) µJbV h¡ &
(D) A{^H$WZ (A) µJbV h¡, naÝVw H$maU (R) ghr h¡ &

13. (A) : Hw$N> {deofk _mZVo h¢ {H$ _mZd OrZmo_ _| 30,000 go A{YH$ OrZ
Adí` hmoZo Mm{hE &
(R) : BZ {g{bH$mo Ûmam OrZ nydm©Zw_mZ H$s A{dídgZr`Vm hr _mZd OrZmo_ _|
H$_ OrZm| H$s [anmo{Q>ªJ Ho$ {bE CÎmaXm`r h¡ & 1

14. (A) : O{Q>b gyú_Ordr` g§dY©Z _mÜ`_ H$m ghr amgm`{ZH$ g§KQ>Z kmV h¡ &
(R) : O~ gyú_Ord H$s {d{eîQ> d¥{Õ Amdí`H$Vm AkmV hmo, Vmo O{Q>b nmofH$
_mÜ`_ H$m Cn`moJ {H$`m OmVm h¡ & 1

15. (A) : ñVZYmar H$mo{eH$mAm| H$s CÎmaOr{dVm (Or{dV ahZo) Ho$ {bE pH H$m
{Z`_Z A{Zdm`© h¡ &
(R) : {ZpíMV pH ~ZmE aIZo Ho$ {bE O§Vw H$mo{eH$m g§dYm] _| A{YH$Va
~mB©H$m~m}ZoQ> - H$m~©Z \$[a¨J àUmbr H$m Cn`moJ {H$`m
OmVm h¡ & 1

16. (A) : nmXn H$mo{eH$m g§dY©Z _| H$Îmm}VH$ H$mo gmo{
CnMm[aV {H$`m OmVm h¡ &
(R) : ©{ZV nm¡Ym| Ho$ n`m©ZwHy$bZ _| ghm`H$ h¡ & 1

1-99 Page 8

For Questions number 13 to 16, two statements are given one labelled as
Assertion (A) and the other labelled as Reason (R). Select the correct answer to these
questions from the codes (A), (B), (C) and (D) as given below.

(A) Both Assertion (A) and Reason (R) are true and Reason (R) is the
correct explanation of the Assertion (A).

(B) Both Assertion (A) and Reason (R) are true, but Reason (R) is not
the correct explanation of the Assertion (A).

(C) Assertion (A) is true, but Reason (R) is false.
(D) Assertion (A) is false, but Reason (R) is true.

13. Assertion (A) : Some experts believe that there must be more than
30,000 genes in human genome.
Reason (R) : Unreliability of in silico gene prediction is responsible for
reporting lesser number of genes in human genome. 1

14. Assertion (A) : The exact chemical composition of complex microbial
growth media is known.
Reason (R) : Complex nutrient media is used when specific growth
requirement of a microorganism is unknown. 1

15. Assertion (A) : The regulation of pH is essential for survival of
mammalian cells.
Reason (R) : Animal cell cultures mostly make use of Bicarbonate
carbon dioxide buffering system to maintain pH. 1

16. Assertion (A) : During plant tissue culture, the explants are treated with
sodium hypochlorite.

Reason (R) : Sodium hypochlorite helps in acclimatization of the
regenerated plants. 1

1-99 Page 9 P.T.O.

IÊS> I

17. EH$ nwZ`m}JO S>rEZE AUw Ho$ {Z_m©U H$mo Xem©Zo hoVw {d{^ÝZ MaUm| H$m {ZXe© {MÌU
H$s{OE & 2

18. OrZ {ZagZ (Zm°H$AmCQ>) dmbo Myho (_mCg) _m°S>b H$m g¥OZ ? 2

19. {XE JE {H$gr EH$ H$mo{eH$m àmê$n H$s g§nyU© àmoQ>rZ àmo\$mBb Ho$ AÜ``Z _| ghm`H$
VH$ZrH$ H$m Zm_ {b{IE & Bg VH$ZrH$ Ho$ {gÕm§V H$s g§{jßV ì`m»`m H$s{OE & 2

20.
Xmo H$m`©-Zr{V`m| Ho$ {df` _| {b{IE & 2

21. (H$) O§Vw H$mo{eH$m Ho$ nmÌo g§dY©Z H$s Xmo H${_`m| (gr_mAm|) Ho$ {df` _| {b{IE & 2
AWdm
(I) (i) EH$ A~w©X-{dkmZr EH$ amoJr H$s Q>çy_a (A~w©X) H$s H$mo{eH$mAm| Ho$ {Zdh
~ZZo H$s {H«$`m H$m Am_mnZ H$a ahm h¡
h¡ ?
(ii) EH$ g§dY© _| g§d{Y©V H$mo{eH$
h¢ & _mZd eara _| hmoZo dmbr n[aKQ>ZmAm| Ho$ gmW BgH$m g§~§Y ñWm{nV
H$s{OE & 2

IÊS> J
22. (H$) {gÕm§V Am¡a Cn`mo{JVm Ho$ g§X^© _| FISH H$s VwbZm gyú_ì`yh Ho$ gmW H$s{OE & 3
AWdm
(I) A{^ì`{º$ VWm àH$m`m©Ë_H$ à 3

23. {ZåZ{b{IV _| go {H$Ýht àmoQ>rZ Am¡f{Y`m| H$mo àmá H$aZo Ho$ {bE àmUr H$mo{eH$m
d§eH«$_ VWm {M{H$Ëgr` Cn`moJ {b{IE : 3
(H$) E[aW«monmoE{Q>Z
(I) hg©opßQ>Z
(J) B§Q>aë`y{H$Z 2
(K) D$VH$ ßbmpµÁ_ZmoOZ g{H«$`H$
1-99 Page 10

SECTION B

17. Illustrate steps to show the construction of a recombinant DNA molecule. 2

18. What are the advantages offered by creating mouse model with gene
knockout ? 2

19. Name the technique that helps to study the entire protein profile from a
given cell type. Briefly explain the principle of this method. 2

20. Write about any two strategies available to enhance the production of
secondary metabolites in plant genetic engineering. 2

21. (a) Give any two drawbacks of animal cell culture in vitro. 2

OR
(b) (i) An oncologist is performing colony formation assay on
tumour cells from a patient. What is he trying to determine ?
(ii) Animal cells growing in culture show the property of contact
inhibition. Relate this to what happens in an adult human
body. 2

SECTION C

22. (a) Compare the techniques of FISH with Microarray in terms of
principle and applications. 3
OR
(b) Differentiate between Expression and Functional Proteomics. 3

23. Write the therapeutic use and the animal cell line employed in obtaining
any three of the following protein pharmaceuticals : 3
(A) Erythropoietin
(B) Herceptin
(C) Interleukin 2
(D) Tissue plasminogen activator

1-99 Page 11 P.T.O.

24. nrgrAma AmdY©Z VH$ZrH$ _| em{_b MaUm| H$s ì`m»`m H$s{OE & 3

25. EH$ emoYH$Vm© Zo gm_mÝ` hr_mo½bm
H$mo{eH$mAm| H$s àmoQ>rZ A§Jw{bN>mnr H$m {ZînmXZ {H$`m & Bg àH«$_ Ho$ àdmh -AmaoI
(âbmoMmQ>©) _| A, B, C H$s g_w{MV eãXm| Ûmam ny{V© H$s{OE & 3

hr_mo½bmo{~Z XmÌH$ma hr_mo½bmo{~Z

A Ûmam CnMm[aV

B

H$mJµO dU©bo{IH$s (nona H«$mo_oQ>moJ«m\$s)

C H$m AZ{Vì`mnr (AZ-AmÀN>m{XV) VWm jm{bV noßQ>mBS>

26. Eogr VrZ {d{Y`m| (VarH$m|) H$s MMm© H$s{OE {OZHo$ Ûmam gyú_Ordr` H$mo{eH$m d¥{Õ H$m
Am_mnZ {H$`m Om gHo$ & 3

27. µOmB_moOZ ? H$mB_mo{Q´>pßgZmoOZ H$mB_mo{Q´>pßgZ go {H$g àH$ma {^Þ h¡ ? 3

28. Eogo VrZ OrZm| Ho$ Zm_ {b{IE {OÝh| nwZ`m}JO S>rEZE àm¡Úmo{JH$s _| daU -`mo½` {M H$ Ho$
ê$n _| Cn`moJ {H$`m Om ahm h¡ & do {Og {deofH$/àmoQ>rZ H$mo {d{Z{X©îQ> H$aVo h¢ CgH$m ^r
CëboI H$s{OE : 3

1-99 Page 12

24. Explain the steps involved in PCR amplification method. 3

25. A researcher performed protein fingerprinting on hemoglobin from both
normal and sickled red blood cells. Complete the flow-chart of the process
by filling A, B, and C. 3

Normal RBC Sickled RBC

Hemoglobin Sickled Hemoglobin

Treat with A

B

Paper Chromatography

C of non-overlapping and eluted peptide

26. Discuss any three ways that can be employed to measure microbial cell
growth. 3

27. What are zymogens ? How is chymotrypsinogen different from
chymotrypsin ? 3

28. Give the names of any three genes that are used as selectable markers in
recombinant DNA technology. Also mention the trait/protein they specify. 3

1-99 Page 13 P.T.O.

IÊS> K
29. ZrMo {XE JE àdmh-
àíZm| Ho$ CÎma {b{IE :
àmoQ>rZ A -MmQ>© `moOZm :

{H$ÊdZ ~«m°W (emoa~m)

AnHo$ÝÐU

ñdÀN> ~«m°W H$mo{eH$m _mÌm (Cell Mass)

{dbm`H$ {ZîH$f©U/H«$mo_¡Q>moJ«m\$s

g§m{ÐV CnmnM`O

n[aîH$aU VWm {H«$ñQ>brH$aU

{dewÕ (n[aîH¥$V) àmoQ>rZ A

(H$) àmoQ>rZ A H$s CËn{Îm A§V:-H$mo{eH$s h¡ AWdm ~mø-H$mo{eH$s ? {b{IE & 1

(I) n[aemoYZ `moOZm _| H$m¡Z-gm MaU CnmnM`O {d{eîQ> h¡ ? 1

(J) 2
AWdm
(J) ? 2

1-99 Page 14

SECTION D

29. Carefully read the below mentioned flow-chart and answer the questions
that follow :

Flow-chart scheme for isolation of Protein A is as given below :

Isolation of Microbial Product

Fermentation Broth

Centrifugation

Clear Broth Cell Mass

Solvent Extraction/Chromatography

Concentrated Metabolite

Purification and Crystallization

Pure Protein A

(a) Write whether Protein A is of intra or extra cellular origin. 1
(b) Which step in the given purification scheme is metabolite specific ? 1
(c) Give the purification scheme for isolation of Humulin from E. coli 2
OR
(c) Why is it advisable to use lesser number of steps for downstream
processing ? 2

1-99 Page 15 P.T.O.

30. ZrMo Xr JB© Vm{bH$m Ho$ n[aàoú` _| g§~§{YV àíZm| Ho$ CÎma {b{IE :

nmXn nmofH$ _mÜ`_ H$mo ~ZmZo _| Cn`moJ {H$E OmZo dmbo g§KQ>H$m| H$s gyMr ZrMo XemB©
JB© h¡ &
nmXn d¥{Õ _mÜ`_ (g§dY©Z _mÜ`_)
g§KQ>H$ _mÌm
NH4NO3 1650 mg/L

CaCl2 440 mg/L

MnSO4 22 mg/L

FeSO4 27 mg/L

½bmBgrZ 2 mg/L

KNO3 1900 mg/L

gwH«$mog 3g/mL

BZmo{gQ>m°b 100 mg/L

EDTA 33 mg/L

(H$) Xr JB© gyMr _| H$m¡Z-gm KQ>H$ H$m~©Z H$m òmoV h¡ ? 1

(I) {dQ>m{_Z Amdí`H$Vm H$s ny{V© hoVw {H$g g§KQ>H$ H$m Cn`moJ {H$`m J`m h¡ ? 1

(J) nmXn g§dY© nmofr _mÜ`_ V¡`ma H$aZo _| gm_mÝ`V: H$m¡Z-go nmXn hm°_m}Zm| H$m {Zdoe
{H$`m OmVm h¡ ? 2
AWdm

(J) à`moJembm _| g§dY©Z _mÜ`_ H$m {ZO©_uH$aU H¡$go {H$`m OmVm h¡ ? ì`m»`m
H$s{OE & 2

1-99 Page 16

30. Consider the following table and answer questions :

Given is a list of ingredients used for preparation of plant nutrient
medium.

Plant Growth Media
Ingredients Amount
NH4NO3 1650 mg/L
CaCl2 440 mg/L
MnSO4 22 mg/L
FeSO4 27 mg/L
Glycine 2 mg/L
KNO3 1900 mg/L
Sucrose 3 g/mL
Inositol 100 mg/L
EDTA 33 mg/L

(a) Which component in the given list is acting as the carbon source ? 1

(b) Which ingredient has been used to fulfill vitamin requirement ? 1

(c) Name two phytohormones which are generally added to prepare
plant nutrient media. 2

OR

(c) Explain how the sterilization of the growth media is achieved in the
laboratory. 2

1-99 Page 17 P.T.O.

IÊS> L>
31. (H$) (i) nZra Ob àmoQ>rZm| Ho$ {M{H$Ëgr` Cn`moJ Ho$ H$maU H$s ì`m»`m H$s{OE & 2
(ii) Eogo Xmo amoJm| Ho$ Zm_ {b{IE {OZH$m nZra Ob Ûmam CnMma {H$`m J`m h¡ & 2
(iii) à{VO¡{dH$m| Ho$ gmW Xhr Ho$ à`moJ H$m ^r nam_e© {X`m OmVm h¡ & ? 1
AWdm
(I) (i) EH$ Zdb (Zmodb) àmoQ>rZ Ho$ {dH$mg H$s MMm© H$s{OE & 3
(ii) Eogo Xmo JwUY_m] Ho$ Zm_ {b{IE {OÝh| àmoQ>rZ B§Or{Z`[a¨J H$m Cn`moJ H$aHo$
nwZì`©dpñWV (_¡{ZnwboQ>) {H$`m Om gH$Vm h¡ ? 2

32. (H$) (i) g|Ja Ho$ û§m¥Ibm g_mnZ {d{Y (MoZ Q>{_©ZoeZ {d{Y) _| ddNTP H$m
g_mdoeZ d¥{Õ H$aVr DNA û§m¥Ibm H$mo g_`nyd© g_mßV H$a XoVm h¡ &
ì`m»`m H$s{OE H¡$go ? 2
(ii) g|Ja H$s DNA AZwH«$_Z û§m¥Ibm g_mnZ {d{Y Ho$ {d{^Þ MaU {b{IE & 3
AWdm
(I) (i) DNA AZwH«$_Z H$s Ad{Y _| _yb AZwH«$_ na nhþ±MZo Ho$ {bE ñd{d{H$aUr
{MÌU (Am°Q>moao{S>`moJ«m_) _| A§{V_ N> mVm h¡ ? 2
(ii) EH$b Q>çy~ DNA AZwH«$_Z {d{Y
OmVm h¡ ? 2
(iii) DNA
H$aZo H$s Amdí`H$Vm hmoVr h¡ & BgHo$ {bE Amn {H$g g§dmhH$ H$mo MwZZm
ngÝX H$a|Jo ? $ 1

33. (H$) (i) EZgr~rAmB© (NCBI) go CnbãY VrZ S>mQ>m~og nwZ: àmß`
{b{IE & do ? 3
(ii) UniprotKB VWm PDB S>mQ>m~ogm| _| {H$g àH$ma H$s gyMZm CnbãY h¡ ? 2
AWdm
(I) (i) AZwH«$_ g_mZVm Ho$ {díbofU _| BLAST H$m Cn`moJ H¡$go {H$`m OmVm h¡ ?
ì`m»`m H$s{OE & 3
(ii) Cg H§$ß`yQ>a àmoJ«m_ (`moOZm) H$m Zm_ {b{IE {OgHo$ Ûmam OrdmUw OrZmo_
VWm gwH|$Ð{H$`m| (`yH¡$[a`mo{Q>H$) Ho$ OrZmo_ H$s
Om gH$Vr h¡ & 2

1-99 Page 18

SECTION E

31. (a) (i) Explain the reason for therapeutic use of whey proteins. 2
(ii) Name any two diseases that have been treated with whey. 2
(iii) Curd is advised to be administered with antibiotics. Why ? 1

OR
(b) (i) Discuss the development of a novel protein. 3

(ii) Name any two properties that can be manipulated using
Protein Engineering. 2

32. (a) (i)
ddNTP cause the growing DNA chains to terminate
prematurely. Explain how. 2
(ii) Briefly write the steps of Sa
of DNA sequencing. 3
OR
(b) (i) During DNA sequencing, why is the autoradiogram read from
bottom to top to arrive at the original sequence ? 2
(ii) Why is single tube DNA sequencing considered better and
safer ? 2
(iii) To perform DNA sequencing of a strand, we need to clone the
sequence in a single-stranded form. Which vector will you
prefer for this ? 1

33. (a) (i) Name three database retrieval tools available from the NCBI.
What all do they allow us to access ? 3
(ii) What kind of information is available in UniProtKB and PDB
databases ? 2
OR
(b) (i) How is BLAST used to analyses sequence similarity ?
Explain. 3
(ii) Name the computer programmes that can perform gene
prediction for bacterial and eukaryotic genomes. 2

1-99 Page 19 P.T.O.

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