PU PhD 2026 Question Paper Faculty of Pharmaceutical Sciences

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PU PhD 2026
Question Paper ·
Faculty of
Pharmaceutical
Sciences
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PU PhD 2026 Question Paper Faculty of Pharmaceutical Sciences

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1. The product formed by the reaction of an aldehyde with a primary amine is known as
________.
(A) Ketone (B) Carboxylic acid (C) Aromatic acid (D) Schiff base
2. Which polymer is most commonly used for osmotic pump tablets?
(A) HPMC (B) Ethyl cellulose (C) Cellulose acetate (D) Eudragit

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3. Chemically lutein is a:

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(A) Coumarin (B) Carotene (C) Terpene (D) Xanthophyll

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4. Which of the following reactions is appropriate for converting amide to amine?

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(A) Carbylamine (B) Stephen's reaction
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5. The a
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(C) Hoffmann bromamide reaction (D) Gabriel's Phthalimide synthesis
major driving force for drug release from a matrix tablet is:
(A) Diffusion (B) Sedimentation (C) Coalescence (D) Flocculation
6. The hydrated proton is also called as ________.
(A) Water proton (B) Hydronium ion (C) Ammonium ion (D) Proton pump
7. Which product will be obtained by Beckmann rearrangement?
(A) Amine (B) Acid (C) Amide (D) None of these
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8. A benzene ring containing two nitrogen atoms at 1,3 position is called ________.
(A) Pyrimidine (B) Pyridine
e m enantiomers is called ________.
(C) Pyrazine (D) Pyridazine
9.
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The separation of racemic mixture into the pure

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(A) Racemization (B) Resolution (C) Isomerization (D) All of these
10. Chemotaxonomy is based on:
(A) Chemical constituents (B) Morphology
(C) Geography (D) Pharmacology
11. Which functional group is most susceptible to hydrolysis?
(A) Alkane (B) Ester (C) Ether (D) Alkene

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12. The major active metabolite of clopidogrel is a __________.

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(A) Carboxylic acid (B) Aldehyde group

c.13.o Which parameter is represented by the Peclet number during spray drying?
(C) Ketone group
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(D) Thiol group
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(B) Diffusion vs solvent

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14. Which heterocyclic ring is present in caffeine?
(D) Surface charge

(A) Quinoline (B) Imidazole (C) Purine (D) Indole
15. Lipinski's Rule of Five predicts:
(A) Oral drug-likeness (B) Toxicity
(C) Stability (D) Crystallinity

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PH.D. 2026 PHARMACY

16. A 20 volume solution of hydrogen peroxide contains:
(A) 3% Hydrogen Peroxide (B) 6% Hydrogen Peroxide
(C) 12% Hydrogen Peroxide (D) 10% Hydrogen Peroxide
17. Radioactive Phosphorus is used in detection of
(A) Malignant neoplasms (B) Dyskinesia
(C) Tinitis (D) Allergic rhinitis
18. Phenolphthalein indicator changes color in the pH range:
(A) 3.1–4.4 (B) 6.0–7.6 (C) 8.3–10.0 (D) 1-3
19. Which excipient mainly acts as a crycoprotectant during lyophilization?
(A) Sodium chloride (B) Mannitol
(C) Talc (D) Magnesium stearate
20. Mohr's method is used to determine:
(A) Sulfate ions (B) Calcium ions
(C) Chloride ions (D) Phosphate ions
21. Eriochrome Black T is commonly used as an indicator in:
(A) Acid-base titration (B) Precipitation titration
(C) Redox titration (D) Complexometric titration
22. Reference electrode commonly used in potentiometry is:
(A) Glass electrode (B) Calomel electrode
(C) Platinum electrode (D) Tungsten electrode
23. The Korsmeyer-Peppas model is used to describe:
(A) Drug release kinetics (B) Drug degradation
(C) Solubility enhancement (D) Permeation coefficient
24. A bathochromic shift refers to shift of absorption maxima to:
(A) Shorter wavelength (B) Higher energy
(C) Longer wavelength (D) No change
25. First-pass metabolism mainly occurs in:
(A) Kidney (B) Lung (C) Liver (D) Spleen
26. In the mechanism of action of penicillins, the strained four-membered β-lactam ring acylates
which specific residue on the bacterial transpeptidase (PBP)?
(A) Serine hydroxyl (B) Cysteine thiol
(C) Histidine imidazole (D) Lysine amino group
27. Pharmacovigilance primarily deals with:
(A) Drug synthesis
(B) Detection and prevention of adverse drug reactions
(C) Formulation development
(D) Herbal standardization

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28. Which sterilization method is most suitable for heat-labile pharmaceutical solutions requiring
terminal sterilization?
(A) Autoclaving (B) Dry heat sterilization
(C) Membrane filtration (D) Ionizing radiation
29. Morphine's semisynthetic derivative, obtained by acetylation at both 3- and 6-OH positions,

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showing enhanced lipophilicity and CNS penetration, is:

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(A) Codeine (B) Naloxone (C) Hydromorphone (D) Heroin

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30. The primary purpose of adding a glidant in tablet formulation is to:

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(A) Improve compressibility

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(B) Reduce interparticulate friction and improve flow
(C) Prevent sticking to punches
(D) Aid disintegration
31. Artemisinin is used primarily in:
(A) Malaria (B) Tuberculosis (C) Cancer (D) Asthma
32. Which of the following is the first step in the research process?
(A) Data analysis (B) Report writing

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(C) Literature review (D) Identification of research problem

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33. The term "pyrogen" in parenteral preparations primarily refers to:
(A) Any particulate contaminant
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(B) Fever-producing substances, typically
(C) Coloring agents
(D) Preservatives causing toxicity
34. Zeta potential is primarily used to evaluate:
(A) Tablet hardness (B) Flow ability
(C) Colloidal stability (D) Moisture content
35. Which of the following is NOT a colligative property?
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(A) Osmotic pressure (B) Vapor pressure lowering

c.36.o The Noyes-Whitney equation describes: e m
(C) Refractive index (D) Freezing point depression

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(B) Rate of dissolution

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37. The therapeutic index is defined as:
(A) ED₅₀/LD₅₀ (B) Vd/Cmax (C) MEC/MTC (D) LD₅₀/ED₅₀
38. Paracetamol overdose is treated using:
(A) Naloxone (B) N-acetylcysteine (C) Flumazenil (D) Atropine

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PH.D. 2026 PHARMACY

39. Statins act by inhibiting:
(A) HMG-CoA reductase (B) Lipoprotein lipase
(C) Cholesterol ester transfer protein (D) Bile acid absorption
40. Drug of choice for treatment of amoebiasis:
(A) Metronidazole (B) Chloroquine (C) Ciprofloxacin (D) Rifampicin
41. Zidovudine is used in the treatment of:
(A) Tuberculosis (B) HIV infection (C) Malaria (D) Fungal infection
42. Lycopodium spore method is used in:
(A) Extraction (B) Chromatography
(C) Quantitative microscopy (D) Bioassay
43. Among which diseases Propranolol is contraindicated :
(A) Hypertension (B) Bronchial asthma
(C) Angina (D) Migraine
44. Clotting factors are secreted from
(A) Liver (B) Pancreas (C) Kidney (D) Lungs
45. Indian Herbal Pharmacopoeia is published by:
(A) ICMR (B) CCRAS (C) IPC (D) IDMA
46. A student injected MPTP to mice. He is working on which disease?
(A) Huntington’s disease (B) Pain
(C) Alzheimer’s disease (D) Parkinson’s Disease
47. Vincristine is obtained from:
(A) Digitalis purpurea (B) Catharanthus roseus
(C) Atropa belladonna (D) Rauwolfia serpentina
48. Sydney Brenner (1974) identified __________ as new animal model for the study of
development.
(A) Drosophila Melanogaster (B) Beagle dogs
(C) Zebra Fish (D) Caenorhabditis elegans
49. Which anticancer drug is based on Helichondrin B?
(A) Paclitaxel (B) Doxorubicin (C) Eribulin (D) Vincristine
50. Which of the following was a major implication of TRIPS for India’s herbal sector?
(A) Abolition of process patents
(B) Introduction of product patents
(C) Exclusive reliance on compulsory licensing
(D) Restriction of exports of herbal drug
x-x-x

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